68Ga-PSMA PET/CT Uptake in the Ureter Caused by Ligand Expression in Urothelial Cancer

68Ga-PSMA PET/CT has become a well-established imaging modality to detect prostate cancer (PCa) metastases in biochemical recurrence. Despite its claimed specificity for PCa, 68Ga-PSMA uptake in tissues unrelated to PCa, particularly in the neovascular tissue of other cancers, has been reported in numerous studies. A 73-year-old man underwent 68Ga-PSMA PET/CT for biochemical recurrence of PCa 7 years after radical prostatectomy. The 68Ga-PSMA PET/CT showed 1 lesion with PSMA uptake in the distal left ureter. Histology revealed a low-grade noninvasive papillary urothelial carcinoma. By immunohistochemistry, PSMA expression was observed in the neoplastic urothelial cells and in the vessels of the papillary structures.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research

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1458Objectives: Physiological renal excretion of 68Ga labelled PSMA may complicate the assessment of pelvic region in prostate carcinoma, with prostatic lesion being obscured by the high radio tracer bladder activity. Thereby can lead to problems in differentiating the pelvic lymph nodes from ureteral activity and challenges in local invasion of prostate carcinoma into the surrounding structures (seminal vesicles, urinary bladder and rectum.The aim of this retrospective study was to assess the utility of diuretic 68Ga-PSMA PET/CT imaging in the loco-regional staging of locally advanced prostate carcinoma. Materials and met...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Prostate Posters Source Type: research
In this study, we investigated the clinical value of diuretic delayed 18F-FDG PET/CT via taking small dose of diuretics orally in diagnosing urogential cancers. To our knowledge, it is the first report which has successfully used the oral intake of small dose of furosemide in diuretic 18F-FDG PET/CT. Methods: Forty-seven patients suspected of urogenital cancers from 2015 to 2017 were divided into small dosage group (26 males and 9 females, aged 33-82 years, 20mg furosemide) and routine dosage group (9 males and 3 females, aged 50-80 years, 40mg furosemide). All patients underwent whole body PET/CT scan (Discovery, GE Healt...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Prostate Posters Source Type: research
The introduction of neo-adjuvant chemo-radiation as standard in addition to surgery for the treatment of locally invasive carcinoma of the rectum has changed the nature and complexity of the urological complications that may arise from the surgery alone. We evaluate the options available in dealing with post-rectal cancer treatment fistulae, as distinct from post-prostate cancer treatment fistulae and identify the difficulties in managing these patients, particularly in the presence of concomitant radiotherapy-related damage to adjacent structures.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Trauma/Reconstruction/Diversion: Ureter (including Pyeloplasty) and Bladder Reconstruction (including fistula), Augmentation, Substitution, Diversion II Source Type: research
Author Affiliations open 1 McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada 2 Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain 3 Universitat Pompeu Fabra (UPF), Barcelona, Spain 4 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain 5 School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada 6 Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA 7 Department of Economics, Brigham Young University, Provo, Utah, USA 8 Population Studies Division, Health Canada, Ottawa, Cana...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
The most common metastatic sites of prostate cancer are the lymph nodes and bone. Ureteral metastasis from prostate cancer is very unusual and only a few cases have been reported.
Source: BMC Urology - Category: Urology & Nephrology Authors: Source Type: research
ABSTRACT Cancer related to hereditary syndromes corresponds to approximately 5-10% of all tumors. Among those from the genitourinary system, many tumors had been identified to be related to genetic syndromes in the last years with the advent of new molecular genetic tests. New entities were described or better characterized, especially in kidney cancer such as hereditary leiomyomatosis renal cell carcinoma (HLRCC), succinate dehydrogenase kidney cancer (SDH-RCC), and more recently BAP1 germline mutation related RCC. Among tumors from the bladder or renal pelvis, some studies had reinforced the role of germline mutations in...
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
We present a 55 year old man with a 2 month history of right flank pain and lower urinary tract symptoms. Prostatic specific antigen of 11.3 ng/mL. Computed tomography showed right hydroureteronephrosis, a developing urinoma and right iliac adenopathies. He underwent right ureteronephrectomy, iliac lymphadenectomy and prostate biopsy. Pathology revealed prostatic carcinoma infiltrating the ureteral muscularis propria, without mucosal involvement. There are 46 reported cases of prostate cancer with ureteral metastases. Ureteral metastasis are a rare cause of renal colic and need of a high index of suspicion.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
This article focuses on mpMRI in the evaluation of urogenital tract malignancies by first reviewing technical aspects and then discussing its potential clinical role. This includes insight into histologic subtyping and grading of renal cell carcinoma and assessment of tumor response to targeted therapies. The clinical utility of mpMRI in the staging and grading of ureteral and bladder tumors is presented. Finally, the evolving role of mpMRI in prostate cancer is discussed. PMID: 26613881 [PubMed - in process]
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Magn Reson Imaging Clin N Am Source Type: research
This article focuses on mpMRI in the evaluation of urogenital tract malignancies by first reviewing technical aspects and then discussing its potential clinical role. This includes insight into histologic subtyping and grading of renal cell carcinoma and assessment of tumor response to targeted therapies. The clinical utility of mpMRI in the staging and grading of ureteral and bladder tumors is presented. Finally, the evolving role of mpMRI in prostate cancer is discussed.
Source: Magnetic Resonance Imaging Clinics of North America - Category: Radiology Authors: Source Type: research
Viral pathogens have been associated with both infectious disease and neoplasia in transplant recipients. Polyomavirus is emerging as a potential causative agent for genitourinary tract cancer in post–kidney transplant patients. Human papillomavirus (HPV) has a proven role in squamous cancers, but has not been studied in genitourinary malignancies in transplantation. Of 2345 kidney transplants performed at our center over the past 20 years, we identified 16 patients with 20 genitourinary cancers (0.7%), including 13 bladder/ureter carcinomas, 5 renal cell carcinomas (RCCs), and 2 prostate carcinomas.
Source: Human Pathology - Category: Pathology Authors: Tags: Original contribution Source Type: research
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