Renal Metastasis From Neuroblastoma Shown on MIBG Imaging

A 6-year-old girl with high-risk neuroblastoma underwent a 123I-MIBG scan to monitor the disease status. In addition to the known lesion in the right retroperitoneal region, there were additional foci of increased activity in the right upper quadrate of the abdomen, which were not typical bowel activity. SPECT/CT images located the activity in the cortex of the lower pole of the right kidney, which was partially calcified. Subsequent biopsy confirmed neuroblastoma metastasis to the right kidney, which is extremely rare.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research

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Conclusions/interpretationThese findings suggest that the anti-DPP6 4hD29 nanobody may become a useful tool for the quantification of human islet grafts in mice and, pending future development, islet mass in individuals with diabetes.
Source: Diabetologia - Category: Endocrinology Source Type: research
We describe increased 123I-MIBG accumulation in the stomach in a 13-year-old girl who had recurrent metastatic neuroblastoma. The activity appeared to be a new MIBG-avid lesion on the planar images. However, the SPECT/CT images revealed that the activity was inside the gastric lumen without anatomical abnormality. On a follow-up 123I-MIBG scan acquired 3 months later, the stomach no longer had elevated MIBG activity, while the other abnormal activity on prior study remained the same.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
157Objectives: Neuroblastoma is the most common extracranial tumors in children, and about half of patients have metastatic disease at presentation (1, 2). I-123-MIBG has been recognized as a radiopharmaceutical of choice in neuroblastoma assessment (3, 4). In recent years, promising diagnostic results are reported by F-18-FDOPA PET-CT after 60-90 min of radiopharmaceutical injection (delay F-18-FDOPA PET-CT) (5, 6). Early F-18-FDOPA PET-CT (3-30 min scan after radiopharmaceutical injection) showed better diagnostic performance in medullary thyroid cancer and brain tumor (7, 8), however, it has not been studied in neurobla...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Pediatrics Source Type: research
In this study, we used both rigid and deformable image registration for each clinical case to register the 4 sequential SPECT/CT scans in the same frame of reference of the first CT scan. Dose rate images were calculated for each time point from the SPECT activity images using a local energy deposition (LED) approach. A voxel-by-voxel fit to an mono-exponential expression was then applied to the aligned dataset to obtain the clearance half-time for each voxel, and the absorbed dose calculated by analytical integration. Once the physical indices of spatial absorbed dose distribution were computed, the radiobiological metric...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Dosimetry Source Type: research
307Objectives: 177Lu-DOTATATE is a somatostatin analog recently approved by FDA and EC as treatment trials for advanced gastroentericpancreatic neuroendocrine tumors (GEP-NET) in adults. However, little data is found on this treatment modality for pediatric neuroblastoma. According to literature data, as much as 33% of children with neuroblastoma were negative on 123I-MIBG and only 30-40% of children with relapsed neuroblastoma responded to 131I-MIBG therapy. We thus aim to investigate whether 177Lu-DOTATATE therapy could be a potential option for children with relapsed neuroblastoma and who were negative on 131I-MIBG/123I...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Pediatrics Source Type: research
Conclusions In the follow-up of patients with high-risk neuroblastoma, SPECT/CT can significantly improve planar imaging interpretation and impact patient management.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Original Articles Source Type: research
AbstractBackgroundNuclear medicine imaging explores tissue viability and function by using radiotracers that are taken up at cellular level with different mechanism. This imaging technique can also be used to assess blood flow and transit through tubular organs. Nuclear medicine imaging has been used in paediatrics for decades and this field is continuously evolving.Sources of dataThe data presented comes from clinical experience and some milestone papers on the subject.Areas of agreementNuclear medicine imaging is well-established in paediatric nephro-urology in the context of urinary tract infection, ante-natally diagnos...
Source: British Medical Bulletin - Category: General Medicine Source Type: research
Conclusion: The improved energy resolution offered by CZT leads to no 99mTc contamination into the 123I window. The CZT low energy tail leads to substantial contamination which can be effectively corrected using a calibration phantom. This evidence shows that using a CZT gamma camera allow us to image 123I-MIBG and 99mTc-MDP simultaneously, and lead to reduction of: sedation, CT exposure, scan duration and overall quantity of appointments for children being treated for neuroblastoma. Research Support: G. Kovalski and N. Schmuel are employees of General Electric HealthCare.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Quantitation Topics in PET and SPECT Source Type: research
Conclusion: 1. Quantitative images of 123I-mIBG SPECT/CT can be generated using a straightforward approach with vendor supplied software and locally determined calibration, independent of the choice of gamma cameras. 2. Quantitation of 123I-mIBG uptake may be useful for objective determination of tumoricidal effect of treatment regimens, particularly for multi-institutional trials. Research Support: $$graphic_4E0330A7-F005-4AF6-B8FA-83F58E1FFC49$$
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Pediatrics Source Type: research
Abstract: A 3-year-old boy with history of neuroblastoma underwent 123I-MIBG scan. The whole-body images showed relatively normal tracer distribution except for mild activity in the right foot, which was located in the first metatarsal on SPECT/CT images. The subsequent MRI scan of the right foot showed infiltration of the metatarsal of the right first toe. The findings were consistent with solitary acrometastasis of neuroblastoma to the great toe.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
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