Solitary Bone Langerhans Cell Histiocytosis Demonstrated on Multimodality Imaging in an Adult

Multimodality imaging was performed on a 53-year-old woman who was suspected with malignant bone tumor in her left femoral midshaft on radiograph. An MRI demonstrated the lesion showed hypointensity on T1-weighted and high intensity on T2-weighted fat-saturated images. It was more extensive on MRI than that on radiograph, especially in bone marrow and parosteal soft tissue. The lesion accumulated radiotracer on bone scan and 18F-FDG PET/CT. Finally, a Langerhans cell histiocytosis was confirmed after surgery. The case cautions us Langerhans cell histiocytosis should be in the differential diagnosis spectrum in an adult with unexplained unifocal bone lesion on 18F-FDG PET/CT.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research

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A 37-year-old white female patient was referred for diagnosis of a lesion on alveolar ridge that extended to the hard palate. In reviewing her medical history, the patient reported headaches that led her to have a computed tomography (CT) scan performed. As a result, fibrous dysplasia of the ethmoidal sinus was diagnosed. Physical examination revealed an ulcerated lesion, with irregular contours, erythroplasic areas, partially covered by fibrin membrane, and without pain. Radiographic examination revealed the destructive character of the lesion, evidenced by the presence of bone loss between teeth 15 and 16.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
ConclusionsA very unusual hip joint lesion of xanthoma disseminatum was replaced with a total artificial joint replacement, and the course over 4  years was good. Our patient’s course will continue to be followed carefully.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Conclusions18F-FDG PET/CT seems to be useful for evaluating LCH when compared to conventional imaging, except in pulmonary cases. It can be used both for staging and restaging purposes.
Source: Japanese Journal of Radiology - Category: Radiology Source Type: research
Abstract OBJECTIVE: Presentation of the etiology, pathology, clinical course, radiology and differential diagnostics of skeletal sarcoidosis. PATHOANATOMICAL PRINCIPLES: Noncaseating epithelioid cell granulomas can trigger solitary, multiple or disseminated osteolysis, reactive osteosclerosis and/or granulomatous synovitis. INCIDENCE: The incidence of sarcoidosis is 10-12 per 100,000 inhabitants per year. Skeletal involvement is approximately 14 %. CLINICAL ASPECTS: Skeletal involvement occurs almost exclusively in the stage of lymph node and pulmonary manifestation. Most cases of skeletal in...
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research
Abstract Erdheim –Chester disease is a rare form of non-Langerhans cell histiocytosis with multi-organ infiltration that occurs mainly in adults. Pediatric cases are extremely rare. Here we report a case of multisystemic Erdheim–Chester disease in a 15-year-old boy with central nervous system involvement and ske letal findings. Positron emission tomography (PET) and MRI were used to demonstrate characteristic bilateral, symmetrical medullary involvement of the metadiaphyses of long bones in the absence of the classic sclerotic radiographic appearance. This illustrates the potential for earlier diagnosis and vi...
Source: Pediatric Radiology - Category: Radiology Source Type: research
Abstract Erdheim–Chester disease is a rare form of non-Langerhans cell histiocytosis with multi-organ infiltration that occurs mainly in adults. Pediatric cases are extremely rare. Here we report a case of multisystemic Erdheim–Chester disease in a 15-year-old boy with central nervous system involvement and skeletal findings. Positron emission tomography (PET) and MRI were used to demonstrate characteristic bilateral, symmetrical medullary involvement of the metadiaphyses of long bones in the absence of the classic sclerotic radiographic appearance. This illustrates the potential for earlier diagnosis...
Source: Pediatric Radiology - Category: Radiology Source Type: research
Abstract A 37-year-old woman with no remarkable medical or family history presented with papules and vesicles on an erythematous background involving the neck, sacrum, and folds (postauricular, axillary, inguinal, and under the breasts) (Figure 1). During the previous year, she was treated with local and systemic antifungals without improvement. Her history included a secondary amenorrhea, polydipsia, and polyuria (6 L/d) that started 2 years prior. Physical examination revealed chronic bilateral purulent otorrhea with thick eardrums. Histologic examination of skin biopsy revealed a highly suggestive appearance of...
Source: Skinmed - Category: Dermatology Authors: Tags: Skinmed Source Type: research
Conclusions In patients undergoing evaluation of LCH, FDG-PET or FDG-PET/CT identified non-osseous disease in 16 of 30 (53%) patients. In 10 (33%) patients, soft tissue disease was distant from osseous disease, was not identified by skeletal survey, and would not have been detected bone scintigraphy. Therefore, in patients with LCH, FDG-PET/CT has clinical utility for identifying non-osseous sites of disease and guiding clinical management.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: MTA I: Other Tumors Posters Source Type: research
Abstract Cysts are commonly seen on CT scans of the lungs, and diagnosis may be challenging. Clinical and radiographic features combined with a multidisciplinary approach may help differentiate among various disease entities, allowing correct diagnosis. It is important to distinguish cysts from cavities as they each have distinct etiologies and associated clinical disorders. Conditions like emphysema, honeycomb lung and cystic bronchiectasis may also mimic cystic disease. A simplified classification of cysts is proposed. Cysts may be present in greater profusion in the sub-pleural areas, when they typically repres...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
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Source: Neurology - Category: Neurology Authors: Tags: Child Neurology and Developmental Neurology: Other Source Type: research
More News: Cancer & Oncology | Histiocytosis | Langerhans Cell Histiocytosis (LCH) | Nuclear Medicine | PET Scan | Radiography