Recent progresses and challenges in graphene based nano materials for advanced therapeutical applications: a comprehensive review

Publication date: Available online 6 December 2019Source: Materials Today CommunicationsAuthor(s): Prabhakar Orsu, Arun KoyyadaAbstractThe peculiar features of graphene like excellent physicochemical, electrical, large surface area and biocompatibility are revealing through the past decade, leading to continuous research on the use of graphene nanomaterial in various clinical applications and regenerative medicine. In this review, we highlighted the recent applications and challenges of graphene and its derivatives in stem cell proliferation, bone tissue engineering, neuronal proliferation and in biosensors. Graphene or graphene oxide has shown interesting results in angiogenesis, neuronal regeneration and immunomodulation in various in vitro and in vivo studies. Graphene based materials have a potential to be emerging as next generation nanomaterials. We discussed about the conventional procedures and related challenges in synthesis of graphene oxide. This review aims in summarizing the recent progresses of various graphene based nanomaterials and their hybrids in biomedical applications. Graphene as two dimensional, three dimensional and hybrids are attracting interest in biosensing and bioimaging. However, besides the fascinating properties of graphene, its biocompatibility and biodegradability related toxicities are still a question to researchers. Graphene nanomaterials use in various tissue scaffolds should be taken as an active area of interest by the researchers in ne...
Source: Materials Today Communications - Category: Materials Science Source Type: research

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Publication date: Available online 25 January 2020Source: Stem Cell ResearchAuthor(s): Yuan Gao, Yanlin Wang, Zhuoya Wang, Huifang Sun, Rui Zhang, Jing Yang, Yutao Liu, Han Liu, Qi Zhang, Shoutao Zhang, Changhe Shi, Yuming Xu, Bo SongAbstractDermal fibroblasts obtained from a 43-year-old healthy man were successfully transformed into induced pluripotent stem cells (iPSCs) by employing episomal plasmids expressing OCT3/4, SOX2, KLF4, LIN28, and L-MYC. The iPSCs showed a normal karyotype and exhibited the potential to differentiate into three germ layers in a teratoma assay, which is often used to assess the pluripotency of ...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
We examined whether Rhy promotes this regulation in bone marrow human mesenchymal stromal cells (BM-hMSCs). Results revealed (i) Rhy modulated biological activity by regulating the mitochondria, N-methyl-D-aspartate receptor subunit, and levels of FGFβ (basic fibroblast growth factor), BDNF (brain-derived neurotrophic factor), OXTR (oxytocin receptor) and ATP (Adenosine triphosphate); (ii) Rhy altered expression level of BM-MSC proliferation/differentiation-related transcription genes; and (iii) interestingly, Rhy amplified the glycolytic flow ratio and lactate dehydrogenase activity while reducing pyruvate dehydrogen...
Source: Cytotherapy - Category: Cytology Source Type: research
Hematopoietic stem cell transplantation (HSCT) is potentially curative for children with life-threatening conditions but can result in a high symptom burden and poor quality of life (QoL). Parents provide extensive care for their children and can experience psychological distress.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
Although therapeutics in Crohn ’s disease (CD) have dramatically improved, current approaches targeting the immune system have limited success at a population level. Thus, there is a need for future therapeutics to target different pathways/cell types. Recently, patient derived stem cells have shown promise in helping to better understand the molecular basis of disease. We used patient derived organoids (PDOs), produced from both CD and healthy patients’ pinch biopsies, to determine the ability of PDOs to functionally represent the human intestinal epithelium, and to better understand the role of the epithelium in CD.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Epithelial Cell Biology/Function in Inflammation Source Type: research
Contributor : Guokai ChenSeries Type : Expression profiling by arrayOrganism : Homo sapienswe use human embryonic stem cells to demonstrate that epidermal ectoderm and subsequent keratinocyte cell fate can be determined step by step under the regulation of defined factors. We show the global gene expression profiles clustered according to the differentiation stages . We also found the human keratinocyte specific gene expression according to the differentiation stages.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Contributors : Brooks D Michael ; Zhu YongyouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThere is substantial evidence that many cancers, including human breast cancer are hierarchically organized and driven by a cellular population that displays stem cell properties. These stem-like cells (CSC ’s) mediate tumor metastasis and by virtue of their relative therapeutic resistance mediate tumor recurrence. Both normal and malignant stem cells are regulated through epigenetic mechanisms which involve DNA and histone modifications as well as noncoding RNAs. However, the mechanisms...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Publication date: April 2020Source: Biomedicine &Pharmacotherapy, Volume 124Author(s): Bissoli Irene, Muscari ClaudioAbstractAccording to cancer stem cell theory, only a limited number of self-renewing and cloning cells are responsible for tumor relapse after a period of remittance. The aim of the present study was to investigate the effects of Doxorubicin and α-Mangostin, two antiproliferative drugs, on both tumor bulk and stem cells in multicellular tumor spheroids originated from the luminal MCF-7 breast cancer cell line. A new and original fluorimetric assay was used to selectively measure the activity of the...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 23 January 2020Source: Stem Cell ResearchAuthor(s): Kim Vanuytsel, Qing Cai, Satish Khurana, Swati Shetty, Joris R. Vermeesch, Laura Ordovas, Catherine M. Verfaillie
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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Source: Cell Cycle - Category: Cytology Authors: Source Type: research
This study extends organoid technology to reptilian tissues and describes an experimentally tractable model system representing the snake venom gland.Graphical Abstract
Source: Cell - Category: Cytology Source Type: research
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