Local extraction and detection of early stage breast cancers through a microneedle and nano-Ag/MBL film based painless and blood-free strategy
Publication date: April 2020Source: Materials Science and Engineering: C, Volume 109Author(s): Liming Chen, Cuicui Zhang, Jiani Xiao, Jie You, Wei Zhang, Yu Liu, Liang Xu, Anwen Liu, Hongbo Xin, Xiaolei WangAbstractEarly diagnosis is the key to the good prognosis of breast cancer. At present, clinical tumor diagnosis is mainly through serum analysis, which is painful and can only detect relatively advanced tumors that have already metastasized from the glands into the blood circulation. Here, we developed an earlier diagnostic method (before tumor cells entering the blood) of breast cancers through a convenient and painless process with blood-free samples. The microneedles were utilized to insert into the animals' testing areas, while the tissue fluid was collected through our synthesized breathable thin film. The obtained tissue fluid sample was then incubated to form blue products. In the area where tumors occurred, the blue changes were more obvious than the healthy area, a semi-localization and semi-quantitative detection of the tumorous area thus could be realized. The results of corresponding animal experiments showed that, after the injection of tumor cells, the proposed nano-Ag based colorimetric method can detect the occurrence of breast cancers in 7 days. What is more, these early tumors could be effectively suppressed through classical DOX treatment. For comparison, the classical blood test needed 14 days to validate the occurrence of breast cancers. The subseq...
In conclusion, drinking GT may have a positive effect on reducing BC risk, especially in long-term, high doses. PMID: 31959020 [PubMed - as supplied by publisher]
Publication date: Available online 22 January 2020Source: Chemico-Biological InteractionsAuthor(s): Yaqiu Wang, Can Liu, Zhihui Xie, Hong LuAbstractTripartite motif (TRIM) protein family is a group of proteins, which belongs to RING family of ubiquitin E3 ligases. TRIM proteins are involved in oncogenesis, while the roles in different cancers are controversial. However, the expression pattern and biological functions of TRIM47 in breast cancer remain unclear. In the present study, we aimed to investigate the function of TRIM47 in the progression and metastasis of breast cancer. TRIM47 was found to be significantly up-regul...
New J. Chem., 2020, Advance Article DOI: 10.1039/C9NJ04961D, PaperElavarasan Nagaraj, Prakash Shanmugam, Kokila Karuppannan, Thirunavukkarasu Chinnasamy, Sujatha Venugopal ZnO/GO nanocomposites were synthesized and their antibacterial activities assessed against various pathogens. They are potential antibacterial materials and significant anticancer activity against the MCF-7 breast cancer cell line compared to the A549 lung cancer cell line. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
I am currently in my senior year of undergrad, and i honestly don't know what my chances of getting into a mid-tier medical school is since my scores are kinda low average. I personally feel i am a little different because im ADHD and Dyslexic and coupled with my experience as a whole. Currently, i have a 3.4 overall GPA scored a 505 on the MCAT The second author on Triple-negative Metaplastic Breast Cancer research paper. I work full time as a Regional Representative for a hemp company... WAMC since i am a not a normal case?
Authors: Wang X, Wen Y, Xue L, Lu R, Tang H, Gao N, Zhang J, Xue Q PMID: 31961109 [PubMed - as supplied by publisher]
Authors: Wang P, Xue L, Wang L, Tang H, Lv C, Xue Q PMID: 31961108 [PubMed - as supplied by publisher]
ConclusionsXJR played an important role in anti-BC through multi-component, multi-target and multi-pathway mechanisms, in which quercetin and ursolic acid may be the key active components. The anticancer effect of multi-component application was better than that of a single component. This study not only deepened our understanding of the role of TCM in the prevention and treatment of diseases, but also provided a reference for the in-depth research, development and application of the ancient medicine.Graphical abstract
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