Value and limitations of intracranial recordings for validating electric field modeling for transcranial brain stimulation

Publication date: Available online 6 December 2019Source: NeuroImageAuthor(s): Oula Puonti, Guilherme B. Saturnino, Kristoffer H. Madsen, Axel ThielscherAbstractComparing electric field simulations from individualized head models against in-vivo intra-cranial recordings is considered the gold standard for direct validation of computational field modeling for transcranial brain stimulation and brain mapping techniques such as electro- and magnetoencephalography. The measurements also help to improve simulation accuracy by pinning down the factors having the largest influence on the simulations. Here we compare field simulations from four different automated pipelines against intracranial voltage recordings in an existing dataset of 14 epilepsy patients. We show that modeling differences in the pipelines lead to notable differences in the simulated electric field distributions that are often large enough to change the conclusions regarding the dose distribution and strength in the brain. Specifically, differences in the automatic segmentations of the head anatomy from structural magnetic resonance images are a major factor contributing to the observed field differences. However, the differences in the simulated fields are not reflected in the comparison between the simulations and intra-cranial measurements. This apparent mismatch is partly explained by the noisiness of the intra-cranial measurements, which renders comparisons between the methods inconclusive. We further demons...
Source: NeuroImage - Category: Neuroscience Source Type: research

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SummaryObjectivePatients with seizures or status epilepticus (SE) access the hospital through emergency departments and may be admitted into different wards according to the level of care required. Clinicians with different expertise are in charge of taking critical therapeutic decisions. To date, very few studies have investigated the stage at which these patients are referred to neurologists or epileptologists and how guideline recommendations are applied in clinical practice.MethodsA survey was used to investigate how patients with epileptic seizures or SE are managed in emergency and in subsequent hospital pathways in ...
Source: Neurological Sciences - Category: Neurology Source Type: research
OBJECTIVE: In the general population, injury related to seizures often involves falls, head trauma, soft tissue injuries, burns and fractures. Additionally, postictal deleterious behavior changes can by experienced by patients. We seek to identify the risk...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Egress, Escape, Evacuation, Crowds Source Type: news
This study examines whether and how se...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Condition:   Epilepsy Interventions:   Drug: OPC-214870;   Other: Placebo Sponsor:   Otsuka Pharmaceutical Development&Commercialization, Inc. Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Publication date: Available online 26 January 2020Source: SeizureAuthor(s): Jacint Sala-Padro, Júlia Miró, Antoni Rodriguez-Fornells, Manolo Quintana, Noemi Vidal, Gerard Plans, Mila Santurino, Mercè Falip, Estela CàmaraAbstractPurposeOur aim was to study the microstructural architecture of the contralateral hippocampus to the affected side in patients with temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and its relation with surgical outcome.MethodWe included 33 consecutive patients evaluated in our epilepsy surgery program during a five-year period. They underwent a presurgical MRI ...
Source: Seizure - Category: Neurology Source Type: research
A drug –drug interaction between cannabidiol and clobazam may explain why cannabidiol reduces the frequency of seizures in patients with a severe form of epilepsy, researchers have reported.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
ConclusionsA wearable EEG device with 2 bipolar channels simplifies the process of obtaining repeated SI quantification allowing a more accurate follow-up of spike activity in the clinical setting.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
AbstractPurpose of ReviewThe purpose of this review is to highlight important clinical aspects in diagnosis and management of epilepsy in the elderly and to highlight recent literature and its relevance to current practice.Recent FindingsRecent studies have shown that elderly patients are under referred for evaluation to epilepsy monitoring units and for epilepsy surgery, which has been demonstrated to be safe and effective in this population.SummaryThe elderly are at increased risk for acute symptomatic seizures and epilepsy. Accurate diagnosis can be challenging in older patients due to limitations in history, atypical s...
Source: Current Geriatrics Reports - Category: Geriatrics Source Type: research
Parry –Romberg syndrome (PRS) was first described by Parry in 1825 and later by Romberg in 1846 [1]. PRS is a rare disorder characterized by unilateral slow progressive facial atrophy that can affect all tissues, from the skin to the osteocartilaginous structures. It is sometimes
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Tags: Review Source Type: research
Source: Nutritional Neuroscience - Category: Nutrition Authors: Source Type: research
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