Safety of systemic therapy for noninfectious uveitis.

Safety of systemic therapy for noninfectious uveitis. Expert Opin Drug Saf. 2019 Dec;18(12):1219-1235 Authors: Ormaechea MS, Hassan M, Onghanseng N, Park JH, Mahajan S, Al-Kirwi KY, Uludag G, Halim MS, Schlaen A, Sepah YJ, Do DV, Nguyen QD Abstract Introduction: The treatment strategies for noninfectious uveitis (NIU) aim to achieve disease remission, prevention of recurrences, and preserving vision, while minimizing the side effects associated with the therapies used.Areas covered: The index review aims to provide a detailed overview of the adverse events and safety parameters associated with the systemic therapies for the management of the NIU.Expert opinion: Despite being the cornerstone of management of acute cases of NIU, long-term corticosteroid use is associated with multi-system side effects, requiring the use of steroid-sparing agents. Adalimumab was recently approved by the FDA for the management of NIU based on the results of VISUAL studies. Similarly, newer drugs targeting various aspects of the inflammatory cascade are being developed. However, until we completely understand the molecular pathways of the inflammatory diseases, the therapeutic profile of these newer agents needs to be broad enough to suppress inflammatory cascade and narrow enough to spare normal cellular processes. Another strategy that has shown some potential in decreasing the systemic side effects is to provide local drug delivery. Therefore, the future of management of NI...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

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ConclusionThe chance of a live birth was not decreased, in women with MS undergoing ART, compared to women without MS. The use of corticosteroids had no impact on the result. These novel results on ART treatment are useful when counseling women with MS undergoing assisted reproduction.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Authors: Abstract Approval of the new topical phosphodiesterase 4 inhibitor crisaborole ointment, 2%, to treat mild-to-moderate atopic dermatitis (AD) warrants careful consideration of available efficacy and safety data for topical therapies to contribute to a better understanding of the role of crisaborole in the treatment of mild-to-moderate AD. A literature review was conducted to identify results of randomized, blinded, vehicle-controlled trials of topical agents for the treatment of AD published from January 1, 1997 to April 30, 2018. This review summarizes the efficacy and safety data of topical therapies in...
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
ConclusionChronic preoperative steroid is not a significant risk factor for surgical site infection following rTKA, but it is independently associated with increased risk of septic shock and prolonged hospital length of stay.
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
Publication date: February 2020Source: JACC: Heart Failure, Volume 8, Issue 2Author(s): Chao Liu, Kunshen Liu
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
Publication date: February 2020Source: JACC: Heart Failure, Volume 8, Issue 2Author(s): Òscar Miró, Koji Takagi, Pere Llorens, Alexandre Mebazaa
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
Publication date: Available online 28 January 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Gayatri B. Patel, Robert C. Kern, Jonathan A. Bernstein, Park Hae-Sim, Anju T. PetersAdvances in understanding the pathogenic mechanisms of both rhinitis and chronic rhinosinusitis have resulted in new treatment options, especially for chronic rhinosinusitis. A review of relevant medical and surgical clinical studies shows that intranasal corticosteroids, antihistamines, and allergen immunotherapy continue to be the best treatments for chronic rhinitis. Dupilumab is the first biologic approved for...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
CONCLUSION: Myocarditis occurring during ICI treatment is a rare but potentially lethal event. Daily serum troponin level seems to predict ICI-related myocarditis but interpretation could be difficult in the context of associated myositis. Echocardiography and cardiac MRI are also useful but can remain negative. Electrocardiogram is a cornerstone of myocarditis diagnosis. In case of cardiac involvement, continuous heart rhythm monitoring should be performed in addition to the administration of high-dose corticosteroids therapy and the cessation of ICI therapy. Add-on treatments should be discussed with a well-trained multi...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Are asthma patients who use inhaled corticosteroids at an increased risk for pneumonia and hospitalization?BMC Pulmonary Medicine
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Pulmonary Medicine Journal Article Source Type: news
We report the case of a 14-year-old boy with diabetes mellitus, who presented with atypical clinical features. He was diagnosed as intestinal mucormycosis and was treated successfully with surgical and antifungal management.
Source: Journal of Indian Association of Pediatric Surgeons - Category: Surgery Authors: Source Type: research
AbstractPurpose of ReviewUnderstanding the origin and shaping the current knowledge of canine atopic dermatitis (cAD) with an emphasis on its similarities and differences with its human counterpart, human atopic dermatitis (hAD), has been the purpose of this study.Recent FindingFundamental research on the ethiopathogenesis and recent specific therapeutic findings have gradually reclassified cAD from a single disease to a multifactorial syndrome.SummaryFrom first being referred to as “red mange” or “canine eczema” in a dog reacting to ragweed pollen, cAD has then been considered to be the canine coun...
Source: Current Dermatology Reports - Category: Dermatology Source Type: research
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