Construction of a Zn(II)-containing MOF for highly selective detection of picric acid and inhibition of human glioma cell growth

Publication date: 15 February 2020Source: Journal of Molecular Structure, Volume 1202Author(s): Yun-Jia Hu, Yu-Ming Li, Kai Zheng, Wei-Hao Zhang, Yu-Li Liu, Hua YangAbstractA novel Zinc-based metal-organic framework [Zn2(OH)2(H2TCPP)](DMF)3 (1) was constructed by using a novel rigid symmetric tetracarboxylic connector, 2,3,5,6-tetrakis (4-carboxyphenyl)pyrazine (H4TCPP). The cross-linkage of Zn(II)-based 1D rod secondary building units (SBUs) with the H2TCPP2− ligands leads to the 3D channel structure of sea-type net with (6,8)-connected topology. Complex 1 not only exhibited the bright blue luminescence induced by H2TCPP2− ligand matrix coordination emission, but also effectively detected picric acid in solution whose quenching constant is 6.95 × 104 M−1. Next, the inhibitory effect of complex 1 on various types of cancer cell lines was detected via CCK-8 method. The influence of complex 1 on the U251 human glioma cells invasion, migration and proliferation ability was further explored via transwell method.
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research

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Source: Methods - Category: Molecular Biology Source Type: research
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