Generation of oxidative stress and induction of apoptotic like events in curcumin and thymoquinone treated adult Fasciola gigantica worms.

In conclusion, both curcumin and thymoquinone generated oxidative stress in the worms by production of ROS and significantly inhibiting their antioxidant and detoxification ability. The oxidative stress along with induction of apoptotic like events would compromise the survival ability of worms within the host. However, further studies are required to establish their anthelmintic potential alone and in combination with the commonly used anthelmintic drugs under in vivo conditions.
PMID: 31801691 [PubMed - as supplied by publisher]

Source: Experimental Parasitology - November 30, 2019 Category: Parasitology Authors: Rehman A, Ullah R, Gupta D, Khan MAH, Rehman L, Beg MA, Khan AU, Abidi SMA Tags: Exp Parasitol Source Type: research