Prognostication with circulating tumor DNA: is it ready for prime time?

This article discusses the methodology for detecting ctDNA in aggressive B-cell lymphomas, including digital polymerase chain reaction, targeted sequencing of immunoglobulin receptors, and targeted next-generation sequencing. The advantages of each of these methods are also compared, with a focus on promising clinical applications. These include identification of molecular subtypes (eg, cell-of-origin and double-hit lymphomas) from pretreatment plasma, molecular response prediction after an initial course of therapy, and early detection of relapsing disease prior to clinical relapse. Finally, this article discusses the challenges in implementing ctDNA assays in the clinic today, including possible solutions to these challenges. PMID: 31808836 [PubMed - in process]
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

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Conclusion: Our series details the unusual circumstances when an eye is removed for intraocular lymphoma. Different patterns of ocular tissue involvement were observed when we compared primary and secondary lymphomas.
Source: RETINA - Category: Opthalmology Tags: Clinicopathologic Correlation Source Type: research
r U Abstract PURPOSE: In the phase 3 DUO trial, duvelisib, an oral dual PI3K-δ,γ inhibitor, demonstrated significantly improved efficacy vs ofatumumab (median [m]PFS, 13.3 vs 9.9 months [HR, 0.52; P
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
ConclusionsDental providers should consider malignancy, including lymphoma, although uncommon, in the differential diagnosis of jaw pain, particularly when thorough evaluation fails to disclose a dental etiology, routine dental interventions fail to control symptoms, or there are atypical clinical or radiographic findings.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
A 32-year-old white woman was referred for evaluation of palate lesion with 3 months ’ duration. Medical history included recent investigation for tuberculosis due to the presence of nodules detected on chest radiograph and previous treatment for syphilis. The patient exam revealed nasal obstruction, cough, secretion drainage, and weight loss. Extraoral examination showed erythema and edema in the face. Moreover, erosive lesions, crusts and purulent drainage were observed in the nasal area. Intraorally, an extensive necrotic lesion with bone destruction and exposure, midline palatal perforation was detected.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
A white 47-year-old woman complained about a lesion in gingiva present for 2 months. Her medical history included systemic erythematosus lupus with previous use of corticosteroids. The intraoral examination revealed an irregularly shaped gingival ulcer in the upper posterior region. Radiographic examination showed no significant abnormalities. According to clinical and radiographic features, malignant or infectious lesions were hypothesized. After an incisional biopsy, microscopic evaluation revealed an intense mixed inflammatory infiltrate with the presence of Reed-Sternberg –like cells of Hodgkin lymphoma.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
This report presents an intraosseous lymphoma that was previously misdiagnosed as periodontal disease. After 3 months of periodontal treatment in a private clinic, a 51-year-old male patient was referred to the stomatology department presenting mandibular swelling and paresthesia lasting 4 months. In his previous history, the patient reported prostatic cancer treated 3 years ago. During intraoral evaluation, an extensive mass with teeth mobility in the right mandible was observed. The radiographic examinations showed an extensive osteolytic lesion, with no limits and cortical perforation in the mandible.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
Delayed onset breast implant-associated reactions range widely in symptomatology and underlying etiology. With increasing reports of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), findings such as unilateral breast swelling, capsular thickening, and peri-implant fluid raise concern. Synovial metaplasia is a benign histologic finding commonly associated with implant capsules and can be an unusual cause of such symptoms. Though the clinical significance of synovial metaplasia is unknown, it is important to consider this entity in the differential diagnosis for delayed onset breast symptoms, with signs o...
Source: Clinical Imaging - Category: Radiology Authors: Tags: Breast Imaging Source Type: research
Corticosteroid-induced regression of lesion contrast enhancement on imaging studies is most commonly appreciated with primary central nervous system lymphoma; however, although exceedingly rare, a limited number of primary and metastatic intracranial lesions have been reported to exhibit similar radiographic changes subsequent to corticosteroid therapy. To date, there have been six cases of glioblastoma reported to exhibit such changes. Lesion transformation on repeat imaging after the initiation of steroids represents a diagnostic dilemma for clinicians when attempting to differentiate between a diagnosis of glioblastoma ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsR/R LBCL is responsive to RT, although rates of response are lower among DHL/THL patients. Given poor survival after RT, in-field control was hard to evaluate in this cohort. Larger cohorts are required to better elucidate whether differences in response rates are driven by larger disease burden at RT versus tumor biology. These findings are of increasing pertinence in light of use of RT as bridging therapy to cellular immunotherapies.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
This study explores associations between age and BPT in a real-world cohort of largely older patients with HL.Material and methodsThis study retrospectively evaluated a nationwide patient cohort of United States Veterans diagnosed with HL in VA medical centers between October 1, 2002 and December 31, 2013 (follow up through April 15, 2016). The primary outcome was the development BPT, defined as: ambient air oxygen saturations 60 years and odds of developing clinically significant BPT.
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
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