Case-based discussion on the implications of exogenous estrogens in hemostasis and thrombosis: the obstetrician's view.

Case-based discussion on the implications of exogenous estrogens in hemostasis and thrombosis: the obstetrician's view. Hematology Am Soc Hematol Educ Program. 2019 Dec 06;2019(1):148-151 Authors: James AH Abstract This is the obstetrician's view on 3 different clinical scenarios involving bleeding and thrombotic disorders. In the first scenario, an 18 year old with a history of heavy menstrual bleeding since menarche presents with abdominal pain and ultrasound findings suggestive of a hemorrhagic ovarian cyst. The association with an underlying bleeding disorder is recognized. The goals of management, which are controlling hemorrhage and preserving fertility, are stated. Ovarian suppression, the most effective method to prevent recurrent hemorrhagic ovarian cysts, is outlined. Long-term management of heavy menstrual bleeding with hormonal contraception is described. In the second scenario, the same patient returns 5 years later for a preconception visit. The potential risks to an unborn baby with von Willebrand disease (VWD) are addressed. The natural rise in von Willebrand factor (VWF) during pregnancy is discussed, but the fact that women with VWD do not achieve the same VWF levels as women without VWD is emphasized and the implications are presented. In anticipation of pregnancy, the need for nonhormonal management of heavy menstrual bleeding and hemorrhagic ovarian cysts is mentioned. In the third and final scenario, the patient's cousin with factor ...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

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Publication date: Available online 14 January 2020Source: Chemical Engineering JournalAuthor(s): Keke Wu, Xiaoxian Wu, Meng Chen, Haoming Wu, Yanpeng Jiao, Changren ZhouAbstractInflammation or infectious wound could produce high level of hydrogen peroxide (H2O2), which may prevent wound healing process. It could be directly monitored the generated H2O2 to determine the wound microenvironment, which related to its healing status. Europium(III) Coordination Polymers (Eu CPs) had the ability to detect the level of H2O2 and promote wound healing. Thus, a H2O2-responsive smart dressing, fabricated by loading Eu CPs into polyacr...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
ConclusionOur findings reveal greater attention towards maternal and child health care especially for the backward districts in the states of UP Uttar Pradesh, MP Madhya Pradesh, Bihar and Rajasthan are needed. Several maternal and social factors leads to the occurrence of low birth weight. Emphasis should be placed on improving the nutritional status of the mothers.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Publication date: Available online 17 January 2020Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Sandy Winfield Jere, Nicolette Nadene Houreld, Heidi AbrahamseAbstractPhotobiomodulation therapy (PBMT) is a curative technique that uses low intensity light to relegate pain and inflammation, and accelerate tissue repair. At a molecular level, the effects of photobiomodulation (PBM) are not fully established. The present study aimed to assess the impact of PBM on the alteration of genes linked to Janus kinase-Signal transducer and activator of transcription (JAK-STAT) signalling in wounded and diabetic...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
This report describes the case of a 20 years old man who was diagnosed with a mass involving the small intestine and bladder during the course of investigations for faecaluria and abdominal pain. Histopathological examination of the biopsies during cystoscopy revealed: muscle invasive transitional cell carcinoma, while the computerized tomography scan had confirmed the enterovesical fistula.The patient was traited by Radical cystectomy with extended pelvic lymph node dissection and ileocecal resection as ultimate curative treatment.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 17 January 2020Source: European UrologyAuthor(s): Kwang Jin Ko, Won Jin Cho, Young-Suk Lee, Joongwon Choi, Hye Jin Byun, Kyu-Sung LeeAbstractBackgroundInterstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition characterized by chronic pelvic pain related to the bladder with no effective treatment options.ObjectiveTo evaluate the efficacy and safety of transurethral resection (TUR) and transurethral coagulation (TUC) as treatments for Hunner lesion (HL) in IC/BPS.Design, setting, and participantsA single-center, prospective, randomized controlled trial involving 126 patien...
Source: European Urology - Category: Urology & Nephrology Source Type: research
ConclusionsRARP with the da Vinci SP is feasible and safe. Therefore, the step-by-step technique described in this study could be considered an option to perform radical prostatectomies. However, we still need better-designed studies to compare the outcomes with those of the multiport platform.Patient summaryWe reported our step-by-step technique describing a safe approach to robotic-assisted radical prostatectomy during the transition from the Xi to the da Vinci single-port robot.
Source: European Urology - Category: Urology & Nephrology Source Type: research
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Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
This study sought to explore gender differences in the reporting of fatigue a...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
AIM: To understand the potential harmful effects of dose escalation among patients with chronic, non-cancer pain (CNCP) on chronic opioid therapy. DESIGN: Retrospective cohort study. SETTING: United States Veterans Healthcare Administration. PARTIC...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
The percentage of ED visits for pain at which an opioid was given or prescribed increased from 37.4% in 2005 to 43.1% in 2010 and then decreased to 30.9% in 2017. A similar pattern was observed in all four regions. Percentages for the Northeast were low...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
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