In MDS, is higher risk higher reward?

In MDS, is higher risk higher reward? Hematology Am Soc Hematol Educ Program. 2019 Dec 06;2019(1):381-390 Authors: Sanz GF Abstract Patients with higher-risk myelodysplastic syndrome (HR-MDS) are defined by the original or revised International Prognostic Scoring System and specific genetic features. Treatment of HR-MDS is challenging. Allogeneic hematopoietic stem cell transplantation, the only curative approach, is feasible in a minority of fit or intermediate fitness patients aged
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Related Links:

Rationale: The success of tyrosine kinase inhibitor (TKI) therapy has greatly prolonged the survival time of patients with chronic myeloid leukemia (CML), harboring the characteristic Philadelphia (Ph) chromosome. However, a fraction of patients, achieving complete cytogenetic response after TKI therapy, develop a myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) with additional clonal chromosomal abnormalities in Philadelphia-negative cells (CCA/Ph–). Patient concerns: A 56-year-old woman with AML, developing from Philadelphia-negative CML after TKI therapy. She showed 6 kinds of somatic variants&m...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
This study aimed to investigate the clinical features and outcomes of patients with myelodysplastic syndrome or acute myeloid leukaemia and Shwachman-Diamond syndrome, an inherited bone marrow failure disorder with high risk of developing myeloid malignancies.MethodsWe did a multicentre, retrospective, cohort study in collaboration with the North American Shwachman-Diamond Syndrome Registry. We reviewed patient medical records from 17 centres in the USA and Canada. Patients with a genetic (biallelic mutations in the SBDS gene) or clinical diagnosis (cytopenias and pancreatic dysfunction) of Shwachman-Diamond syndrome who d...
Source: The Lancet Haematology - Category: Hematology Source Type: research
In this study, by adenovirus-mediated delivery and inducible transgenic mouse models, we demonstrate the proliferation of both HCs and SCs by combined Notch1 and Myc activation in in vitro and in vivo inner ear adult mouse models. These proliferating mature SCs and HCs maintain their respective identities. Moreover, when presented with HC induction signals, reprogrammed adult SCs transdifferentiate into HC-like cells both in vitro and in vivo. Finally, our data suggest that regenerated HC-like cells likely possess functional transduction channels and are able to form connections with adult auditory neurons. Epige...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Killer immunoglobulin-like receptor (KIR) genes participate in the regulation of natural killer (NK) cell function, and mismatch between transplant donor and recipient improves clinical outcomes in some transplantation settings [1-6]. Lower than expected rates of relapse, graft failure, and graft-versus-host disease (GVHD) occur in KIR-incompatible, T cell-depleted, HLA-mismatched related donor hematopoietic stem cell transplantation (HSCT) for acute myelogenous leukemia (AML) [5]. Similarly, Hsu et al [7] reported superior overall survival (OS) and disease-free survival (DFS) for recipients of KIR-incompatible HCST compar...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Today I'll point out a pair of open access review papers in which the authors discuss mechanisms involved in the age-related declines and detrimental altered behaviors of hematopoietic stem cells. These stem cells are responsible for generating blood and immune cells, and so are of vital importance to the function of the immune system throughout life. One paper focuses on external contributions, those arising from the surrounding environment, while the other looks at damage and change arising from the stem cells themselves. This encapsulates the divide in thinking about stem cell aging in general. At least some stem...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
ConclusionsOral complications in HSCT survivors are common and may include GVHD, dry mouth, and taste changes. All patients must be screened prior to HSCT and followed up by a dentist periodically to assess the oral health status and modify treatment, if needed.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Authors: Cloos J, Ossenkoppele GJ, Dillon R Abstract Risk classification and tailoring of treatment are essential for improving outcome for patients with acute myeloid leukemia or high-risk myelodysplastic syndrome. Both patient and leukemia-specific characteristics assessed using morphology, cytogenetics, molecular biology, and multicolor flow cytometry are relevant at diagnosis and during induction, consolidation, and maintenance phases of the treatment. In particular, minimal residual disease (MRD) during therapy has potential as a prognostic factor of outcome, determination of response to therapy, and direction...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Conclusion: BOS is a high mortality complication that appears in a 15% of allogeneic HCT. Its management must be multidisciplinary because It may develops alone or associated with other organs disease. Respiratory function tests are necesary in extrapulmonary GVHD cases, as well as in patients with respiratory symptoms to detect premature pulmonary involvement and to establish early treatment.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
In this study, we analyzed a well-defined consecutive series of 98 patients with acute myelogenous leukemia/myelodysplastic syndrome (AML/MDS) who received allogeneic stem cell transplantation with non-myeloablative (NMA) conditioning to determine risk factors associated with the severity of cGVHD. cGVHD was defined according to the 2005 National Institute of Health consensus criteria. Transfusions before transplantation, presence of HLA antibodies, composition of the graft (CD3+, CD19+, CD34+ cells), sibling or matched unrelated donor, female donor to male recipient, CMV serology and the development of acute GVHD (aGVHD),...
Source: Human Cell - Category: Cytology Source Type: research
More News: Acute Leukemia | Acute Myeloid Leukemia | Allergy & Immunology | Clinical Trials | Education | Genetics | Hematology | Leukemia | Myelodysplastic Syndrome | Stem Cell Therapy | Stem Cells | Study | Transplants | Universities & Medical Training