Preoperative anemia-screening clinics.

Preoperative anemia-screening clinics. Hematology Am Soc Hematol Educ Program. 2019 Dec 06;2019(1):570-576 Authors: Lin Y Abstract Preoperative anemia is associated with increased postoperative morbidity and mortality and with increased risk of perioperative transfusion. It is an important and modifiable risk factor for surgical patients. For high-blood-loss surgery, preoperative anemia is defined as hemoglobin
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

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Publication date: Available online 26 January 2020Source: Advances in Biological RegulationAuthor(s): Andrew T. Hale, Rachel E. Brown, Zigmund Luka, Benjamin H. Hudson, Pranathi Matta, Christopher S. Williams, John D. YorkAbstract:Sulfur assimilation is an essential metabolic pathway that regulates sulfation, amino acid metabolism, nucleotide hydrolysis, and organismal homeostasis. We recently reported that mice lacking bisphosphate 3’-nucleotidase (BPNT1), a key regulator of sulfur assimilation, develop iron-deficiency anemia (IDA) and anasarca. Here we demonstrate two approaches that successfully reduce metabolic t...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
A new study indicates that the antithrombotic efficacy of NOACs are reduced in anemic patients. Should patients with AF and moderate to severe anemia receive oral anticoagulants?European Heart Journal
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news
Contributors : Alexander Azzo ; Xiaofei Yu ; Mikhail Dozmorov ; Gordon D GinderSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAs high fetal hemoglobin (HbF) levels ameliorate the underlying pathophysiologic defects in sickle cell anemia and β-thalassemia, understanding the mechanisms that enforce silencing of HbF postnatally offers the promise of effective molecular therapy. Depletion of Methyl cytosine Binding Domain protein 2 (MBD2) causes a 10-20 fold increase in γ-globin gene expression in adult β-YAC transgenic mice. To determ ine the effect of MBD2 depletion in ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Authors: Pastor-Galán I, Hernández-Boluda JC, Correa JG, Alvarez-Larrán A, Ferrer-Marín F, Raya JM, Ayala R, Velez P, Pérez-Encinas M, Estrada N, García-Gutiérrez V, Fox ML, Payer A, Kerguelen A, Cuevas B, Durán MA, Ramírez MJ, Gómez-Casares MT, Mata-Vázquez MI, Mora E, Martínez-Valverde C, Arbelo E, Angona A, Magro E, Antelo ML, Somolinos N, Cervantes F, en representación del Grupo Español de Enfermedades Mieloproliferativas Filadelfia Negativas (GEMFIN) Abstract BACKGROUND AND OBJECTIVE MYELOFIBROSIS: is an infrequen...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
AbstractBackgroundThe purpose of this study is to investigate the performance of dual-layer detector spectral CT for iron deposition compared to magnetic resonance imaging (MRI) T2* imaging.MethodsThirty-one patients with a clinical history of myelodysplastic syndromes and aplastic anemia underwent liver and cardiac T2*-weighted unenhanced MRI on a three-tesla MRI scanner, and underwent unenhanced CT scan laterally on a 128-row spectral detector CT. R2* values of the liver, septal muscle, and paraspinal muscle were calculated. Attenuation differences ( ΔH) in the liver and myocardium were calculated between the lower...
Source: Japanese Journal of Radiology - Category: Radiology Source Type: research
Publication date: Available online 25 January 2020Source: Revista Clínica Española (English Edition)Author(s): M. Quintana-Díaz, E.M. Andrés-Esteban, J. Sánchez-Serrano, A. Martínez-Virto, R. Juárez-Vela, J.A. García-ErceAbstractIncreasing haemoglobin and haematocrit levels with blood transfusions has been the gold standard for treating severe anaemia; however, the indication for transfusing concentrated red blood cells is based merely on a few laboratory markers, such as haemoglobin and haematocrit levels, rather than based on the symptoms according to clinical pract...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
This study is registered with ClinicalTrials.gov, NCT01243944.FindingsWe enrolled patients between Oct 27, 2010, and Feb 13, 2013, and the study concluded on Feb 9, 2018. Of 342 individuals screened for eligibility, 222 patients were randomly assigned to receive ruxolitinib (n=110, 50%) or best available therapy (n=112, 50%). The median time since polycythaemia vera diagnosis was 8·2 years (IQR 3·9–12·3) in the ruxolitinib group and 9·3 years (4·9–13·8) in the best available therapy group. 98 (88%) of 112 patients initially randomly assigned to best available therapy cr...
Source: The Lancet Haematology - Category: Hematology Source Type: research
Anemia is a common systemic complication of inflammatory bowel disease (IBD), with reported prevalence up to 74%. Anemia is associated with worse disease outcome and quality of life. The Crohn ’s and Colitis Foundation recently published an initiative quantifying the healthcare cost of IBD patients. They found that the presence of anemia was associated with high resource utilization, particularly hospitalization. The purpose of this study was to determine how anemia severity impacts hea lthcare utilization and if treatment of anemia reduces healthcare utilization.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Disease Complications Source Type: research
Iron deficiency Anemia (IDA) is a common complication of inflammatory bowel disease (IBD). High prevalence of IDA in IBD suggests suboptimal surveillance and treatment. Oral iron is poorly tolerated, associated with worsened disease activity, and often insufficient to reverse anemia in IBD patients. Intravenous (IV) iron is favored for treatment of IDA in IBD in most clinical scenarios and many guidelines recommend IV iron as first line for IBD patients. Regardless, oral iron is prescribed commonly for IDA in IBD.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Practice Management/Quality of Care/Quality Assurance Source Type: research
Anemia is frequently encountered in inflammatory bowel disease (IBD) with studies reporting an even greater prevalence among children (16-72%) than adults (4-67%) at any given time during disease course. Anemia is commonly a result of chronic iron deficiency (ID) and inflammation, with the two conditions often overlapping. Many studies have shown that gastroenterologists underecognize and undertreat these conditions. Moreover, there are currently no pediatric-specific guidelines. To align clinical practice with adult guideline recommendations and evidence-based publications, we developed a quality improvement (QI) initiati...
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Practice Management/Quality of Care/Quality Assurance Source Type: research
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