Tetrasubstituted α-pyrone derivatives from the endophytic fungus, Neurospora udagawae

Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Allan Patrick G. Macabeo, Allaine Jean C. Cruz, Abolfazl Narmani, Mahdi Arzanlou, Asadollah Babai-Ahari, Luis Agustin E. Pilapil, Katherine Yasmin M. Garcia, Volker Huch, Marc StadlerAbstractTwo new α-pyrone derivatives, udagawanones A (1) and B (2), along with the known compounds (Z)-4-hydroxy-3-(3-hydroxy-3-methylbut-1-en-1-yl)benzoic acid (3), isosclerone (4), cyclo-(L-Leu-L-Pro) (5), and cyclo-(L-Pro-L-Tyr) (6), were isolated from cultures of the endophyte Neurospora udagawae. Their structures were elucidated by extensive spectroscopic methods and single crystal X-ray diffraction. Both compounds feature oxidized functionalities at the C-2 position not previously observed in other tetrasubstituted α-pyrones from fungi. Compound 1 exhibited moderate antibacterial (vs. Staphylococcus aureus) and antifungal (vs. Rhodoturula glutinis) activities and cytotoxicity against KB3.1 cells.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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