The Relationship Between BMI, Body Composition, and Fat Mass Distribution in Rou-en-Y Gastric Bypass Patients

AbstractBackgroundType 2 diabetes mellitus (T2DM) with central obesity is a common clinical presentation in Chinese patients. Body mass index (BMI) is a criterion determining central obesity that, when combined with dual-energy X-ray absorptiometry (DXA), accurately reflects body composition and fat mass distribution. The utility of DXA-derived measures in the evaluation of metabolic surgery still needs to be investigated.MethodsIn this cohort study, 78 Chinese patients with central obesity (WC  ≥ 90 cm for males, WC ≥ 85 cm for females) or BMI above 27.5 kg/m2 underwent gastric bypass between October 2010 and October 2012. The patients were followed for 12  months. Preoperative, perioperative, and postoperative metabolic parameters and DXA results were prospectively collected and analyzed.ResultsA total of 57 of 78 cases (73.1%) were diagnosed with central obesity. There was a significant decrease in BMI, WC, and WHR at each point in time (P 
Source: Obesity Surgery - Category: Surgery Source Type: research

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This study aimed to investigate the irisin levels in elderly patients with hypertension, diabetes mellitus type 2, and overweight and obesity, to investigate the possible association between irisin levels and anthropometric and biochemical parameters, and also to assess the irisin levels associated with a risk of hypertension, diabetes mellitus type 2, and overweight and obesity.MethodsA nested case-control study was conducted, with hypertension, diabetes mellitus type 2, and overweight and obesity being set as the case group; 71 elderly patients from the cohort were enrolled in each case group, and 71 healthy elderly from...
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
This study aims to understand the progression of two chronic diseases in the Australian health context. It specifically focuses on the comorbidity progression of cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (T2DM), as the prevalence of these chronic diseases in Australians is high. A research framework is proposed to understand and represent the progression of CVD in patients with T2DM using graph theory and social network analysis techniques. Two study cohorts (i.e., patients with both T2DM and CVD and patients with only T2DM) were selected from an administrative dataset obtained from an Australi...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
In this study, we investigated casein kinase 2 alpha 1 (CSNK2A1) gene and protein expression in the liver tissues of mice at different ages (4, 16, and 32 weeks) using real-time quantitative polymerase chain reactions, western blotting, immunohistochemistry, and enzyme-linked immunosorbent assay. Our data paved the way for exploring BKS.Cg- Dock7m +/+ Leprdb/JNarl in the mouse model by demonstrating a significant increase in gene and protein expression in T2DM (+Leprdb/+Leprdb) mouse liver when compared to control (+Dock7m/+Dock7m) mouse liver. We also observed that CSNK2A1 protein level in the serum of T2DM patient group ...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Publication date: Available online 13 January 2020Source: Medical Journal Armed Forces IndiaAuthor(s): Rajvir BhalwarAbstractMetabolic Syndrome (MetS) is a clustering of specific risk factors, namely, central obesity, raised blood pressure, impaired fasting glucose, raised triglycerides, and low levels of high-density lipoprotein-cholesterol (HDL-C). This constellation is triggered by insulin resistance and its resultant hyperinsulinemia. The two most important and universally agreed causes of insulin resistance are increased body fat (particularly central obesity) and physical inactivity. Other causes include certain gene...
Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
Publication date: Available online 13 January 2020Source: Pharmacological ResearchAuthor(s): John O. Orgah, Shuang He, Yule Wang, Miaomiao Jiang, Yuefei Wang, Emmanuel A. Orgah, Yajun Duan, Buchang Zhao, Boli Zhang, Jihong Han, Yan ZhuAbstractMetabolic syndrome, such as diabetes mellitus, obesity, atherosclerosis, and high blood pressure (HBP), are closely linked pathophysiologically. However, current monotherapies for metabolic syndrome fail to target the multifactorial pathology via multiple mechanisms, as well as resolving the dysfunctionality of the cells and organs of the body. We aimed to provide a comprehensive and ...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Conditions:   Diabetes Mellitus Type 2 in Obese;   Inflammation;   Metabolic Disease;   Glucose Metabolism Disorders (Including Diabetes Mellitus) Intervention:   Drug: Anakinra Prefilled Syringe Sponsor:   University Hospital, Basel, Switzerland Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, our study showed the risk of the assessed variants for the development of T2DM in the Saudi population.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
We examined the relationship between maternal obesity at the first prenatal visit and fasting lipids measured at the time of the oral glucose tolerance test (OGTT) in women screened selectively for GDM.Study DesignThis prospective observational study was conducted in a large university maternity hospital. Women were recruited at the first prenatal visit following measurement of their weight and height. Clinical and sociodemographic details were recorded. Women with maternal risk factors for GDM, were screened selectively with a one-step 75 g OGTT at 26-28 weeks gestation. GDM was diagnosed based on the World Health ...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
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