Useful Imaging to Detect Macrophage Localization in the Media and Adventitia of the Abdominal Aortic Aneurysm Wall Using Ex Vivo Superparamagnetic Iron Oxide-enhanced Magnetic Resonance Imaging

Introduction: Macrophages in the aneurysmal wall play an important role in the pathogenesis of abdominal aortic aneurysms (AAAs). superparamagnetic iron oxide (SPIO) is a macrophage-specific contrast agent that result in negative enhancement on T2*-weighted imaging. SPIO-enhanced MRI targeting the mural thrombus of AAAs was reported, and the signal level of thrombi showed a decrease after SPIO injection. However, the macrophages in the media and adventitia of AAA wall has not been investigated in detail.

Source: European Journal of Vascular and Endovascular Surgery - November 30, 2019 Category: Surgery Authors: Michihisa Umetsu, Hitoshi Goto, Daijirou Akamatsu, Hirofumi Sugawara, Ken Tsuchida, Yoshitaro Yoshida, Shunya Suzuki, Shinichiro Horii, Takashi Kamei Source Type: research