The Effects of a Multimodal Approach for the Treatment of Primary Progressive Aphasia

Condition:   Primary Progressive Aphasia Interventions:   Device: Active tDCS;   Device: Placebo tDCS;   Behavioral: Language training;   Behavioral: Unstructured cognitive training Sponsors:   IRCCS Centro San Giovanni di Dio Fatebenefratelli;   Azienda Ospedaliera Spedali Civili di Brescia Not yet recruiting
Source: - Category: Research Source Type: clinical trials

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Publication date: Available online 24 January 2020Source: Journal of Clinical NeuroscienceAuthor(s): Seung Hwan Kim, Hyungon Lee, Hye-Jin Kim, Byeong-Sam Choi, Sung-Chul JinAbstractSuperficial temporal artery (STA)-middle cerebral artery (MCA) bypass surgery is considered not the primary but the last treatment option for acute atherosclerotic occlusions refractory to medical treatment. We retrospectively evaluated patients who underwent STA-MCA bypass surgery for acute atherosclerotic occlusion intractable to other treatments. From June 2010 to May 2014, 10 patients underwent STA-MCA bypass surgery for acute atheroscleroti...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Goals of care discussions are frequently indicated after acute stroke. Many of these conversations happen without direct patient participation secondary to aphasia or encephalopathy.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
AbstractPurpose of the ReviewAlthough visual and somatosensory disturbances are the most common migraine aura (MA) symptoms, patients can also experience other symptoms during their MA. The aim of this review is to provide an overview of studies that report symptoms of dysphasia and other higher cortical dysfunctions (HCDs) during MA, as well as to determine the frequency of HCDs.Recent FindingsFive studies met the inclusion criteria, corresponding to 697 patients overall. The most frequently reported HCDs were those of the language group (range 10 –53%). The occurrence of visual HCDs was noted in 12–40 patient...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
Conclusions: We speculated that damages to the basal ganglia disrupted the cortico-subcortical circuits that facilitated the transhemispheric communications of language functions, resulting in decreased interhemispheric FC. Consequently, the intrahemispheric FC increased as a possible compensatory mechanism to restore the language functions. PMID: 31955634 [PubMed - as supplied by publisher]
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
ConclusionsThis patient demonstrates an unusual presentation of glioblastoma multiforme as thalamic aphasia. It may also point to the potential contribution of the understanding of how thalamic aphasia evolves to characterize the role of the thalamus in language functions.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 20 January 2020Source: NeuropsychologiaAuthor(s): Maria Dekhtyar, Swathi Kiran, Teresa GrayAbstractThe bilingual advantage proposes that bilingual individuals have enhanced cognitive control compared to their monolingual counterparts. Bilingualism has also been shown to contribute to cognitive reserve by offsetting the behavioral presentation of brain injury or neural degeneration. However, this effect has not been closely examined in individuals with post-stroke or post-TBI aphasia. Because bilingualism has been suggested as a factor of cognitive reserve, it may provide protective mechan...
Source: Neuropsychologia - Category: Neurology Source Type: research
ConclusionRegardless of its rarity, it is evident that damage in the left SMA usually results in a clinical syndrome that clearly corresponds to aphasia. Interpreting this as an aphasia can aid in overcoming the limited idea of a “language zone” located in the perisylvian area of the left hemisphere, that was proposed over one century ago.
Source: Journal of Neurolinguistics - Category: Speech-Language Pathology Source Type: research
An elderly woman with h/o stroke and aphasia seemed different to her daughter, and was pointing all over her body as if in pain.They called 911.She had a history of PCI to the circumflex and also of severe mitral regurgitation, status post bioprosthetic valve replacement.  Also a h/o LV aneurysm with thrombus, on anticoagulation, as well as a dual chamber pacemaker. On arrival, the BP was 60/30.Here is the initial ECG:There is atrial pacing and Right Bundle Branch Block (RBBB)There is STE in I and aVL, V5, V6, with reciprocal STD in II, III, aVFThere is appropriately discordant ST depression in V1-V3 (appropriate...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
Discussion:GJB1 mutations form a clinical spectrum, including most patients with peripheral nerve involvement, those with both peripheral neuropathy and CNS involvement, and patients with CNS involvement only.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Source: Aphasiology - Category: Speech-Language Pathology Authors: Source Type: research
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