Effects of SIMEOX on Airway Clearance in Cystic Fibrosis

Condition:   Cystic Fibrosis Interventions:   Other: Autogenic drainage;   Device: SIMEOX + Autogenic drainage Sponsor:   Cliniques universitaires Saint-Luc- Université Catholique de Louvain Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Authors: Louagé A, Knoop C, Hanssens L Abstract INTRODUCTION: The aim of this study was to evaluate the impact of the transition period from childhood to adulthood in patients with cystic fibrosis (CF) being followed up in our reference center. METHODS: The clinical, functional, inflammatory and microbiological parameters of all transition patients were compared two years before (T-2) and two years after the transfer (T+2) from paediatric to adult centers and further analysed according to whether the transition conditions were optimal or suboptimal. RESULTS: Twenty-eight patients were included. The m...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Pulmonary disease remains the most significant determinant of morbidity and mortality in cystic fibrosis (CF). Patients with CF typically experience progressive decline in lung function punctuated by pulmonary exacerbations [1], acute episodes characterized by worsened cough and sputum production and thickness, as well as decreases in pulmonary function, appetite, and weight. Over 34% of patients with CF are treated with IV antibiotics for an exacerbation each year [2]; median duration of hospitalization for these events is 9.3 days, and the median duration of IV antibiotics is 13 days [2].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
Autosomal recessive diseases, such as cystic fibrosis (CF), require inheritance of 2 mutated genes. However, some studies indicate that CF carriers are at increased risk for some conditions associated with CF. These investigations focused on single conditions and included small numbers of subjects. Our goal was to determine whether CF...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
Condition:   Cystic Fibrosis Intervention:   Drug: LUM/IVA Sponsor:   Vertex Pharmaceuticals Incorporated Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
SIX young cystic fibrosis sufferers get their hands on boxes of lifesaving pills at last after fighting in our crusade to win an NHS deal. Last year, all six spoke out in separate, tear-jerking Daily Express stories to plead for the medications produced by US firm Vertex.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Cystic fibrosis related diabetes (CFRD), a common complication in cystic fibrosis, is associated with worse clinical outcomes [1 –4], and increases disease burden while adversely impacting quality of life [5]. Early diagnosis and treatment of CFRD may mitigate the associated decline in lung function, decreases in body mass index (BMI), and increased mortality [6–8]. Earlier glucose derangements during 75 g oral glucose c hallenge test (OGTT) such as impaired glucose tolerance (IGT; 2-hr OGTT glucose ≥7.8 mmol/L and
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Short Communication Source Type: research
Authors: Zupani─Ź MV, Škerjanc A Abstract OBJECTIVE: Cystic fibrosis is a genetic disorder that affects mostly lungs but also other organs. Modern treatment has transformed once fatal disease of childhood into the chronic disease of adulthood. Hence more patients enter the job market. Very few adolescents with cystic fibrosis receive some formal career guidance. There is still no professional career guidance for them in Slovenia. METHODS: Literature on workability of patients with cystic fibrosis was reviewed. Following the articles and Slovenian and foreign manuals the guidelines on career counselling o...
Source: Central European Journal of Public Health - Category: International Medicine & Public Health Tags: Cent Eur J Public Health Source Type: research
BRAVE cystic fibrosis sufferer Ayden Cochrane wept with joy last night, after we helped him secure the American wonder pill that could save his life. In a dramatic change of heart, drug maker Vertex contacted the Daily Express directly, telling us Ayden, 13, will receive Trikafta in the next 24 hours.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AbstractPurpose of ReviewThe understanding of the human microbiome, especially of the oral cavity, has expanded exponentially since the advent of 16 rRNA PCR gene sequencing. Since the respiratory tract starts from the oral cavity and ends in the lung, study of the relationship between the oral microbiota and the lungs will allow us to understand the changes in lung disease compared with healthy state.Recent FindingsThe oral and lung microbiota were found to be similar, but the oral microbiota had greater diversity. The oral cavity especially the dorsal tongue was found to be a reservoir for bacteria causing pneumonia and ...
Source: Current Oral Health Reports - Category: Dentistry Source Type: research
What makes the Antabio ’s molecule candidate so unique is that it’s not an antibiotic. Antibiotics typically work by killing bacteria, whereas this molecule aims to disable the bacteria, making it less able to attack and inflame the lungs.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
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