Primary Sarcomas of the Larynx: A Single Institutional Experience with Ten Cases

In conclusion, primary sarcomas of the larynx a re rare but tend to present with early symptoms. This likely allows for earlier detection and intervention as compared to their counterparts in other deep soft tissue locations. Pathologically, it is important, although difficult in some cases, to distinguish these neoplasms from sarcomatoid carcino ma and reactive processes. Careful morphologic and immunohistochemical evaluation, as well as correlation with the clinical and radiologic findings, is important for accurate tumor classification.
Source: Head and Neck Pathology - Category: Pathology Source Type: research

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Publication date: Available online 2 July 2019Source: Pharmacology &TherapeuticsAuthor(s): Elizabeth Thoenen, Amanda Curl, Tomoo IwakumaAbstractGenomic and functional study of existing and emerging sarcoma targets, such as fusion proteins, chromosomal aberrations, reduced tumor suppressor activity, and oncogenic drivers, is broadening our understanding of sarcomagenesis. Among these mechanisms, the tumor suppressor p53 (TP53) plays significant roles in the suppression of bone and soft tissue sarcoma progression. Although mutations in TP53 were thought to be relatively low in sarcomas, modern techniques including whole-...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
ConclusionsPET –CT in high-grade bone and soft tissue sarcoma can add significant benefit to routine CT/MRI staging. Further prospective and multi-centre evaluation of PET–CT is warranted to determine the actual predictive value and cost-effectiveness of PET–CT in directing clinical management of clinically complex and heterogeneous high-grade sarcomas.
Source: Clinical Sarcoma Research - Category: Cancer & Oncology Source Type: research
23Objectives: 18F-FDG-PET/CT is commonly used for the staging of patients with sarcomas and many centers routinely include the upper and lower extremities in the field of view of the PET/CT study. Imaging of the extremities significantly increase the duration of the PET/CT study, and the CT component results in a non-trivial additional radiation dose. But the clinical value of routinely imaging the extremities is not well established. The aim of this study was therefore to investigate in a large series of patients how frequently new, clinically relevant information is obtained from 18F-FDG-PET/CT images of the upper and lo...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Sarcoma/ Melanoma Source Type: research
Conditions:   Adult Alveolar Soft Part Sarcoma;   Adult Angiosarcoma;   Adult Epithelioid Sarcoma;   Adult Extraskeletal Myxoid Chondrosarcoma;   Adult Extraskeletal Osteosarcoma;   Adult Fibrosarcoma;   Adult Leiomyosarcoma;   Adult Liposarcoma;   Adult Malignant Mesenchymoma;   Adult Synovial Sarcoma;   Adult Unclassified Pleomorphic Sarcoma;   Childhood Alveolar Soft Part Sarcoma;   Childhood Angiosarcoma;   Childhood&...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Adult Fibrosarcoma;   Alveolar Soft Part Sarcoma;   Angiomatoid Fibrous Histiocytoma;   Atypical Fibroxanthoma;   Clear Cell Sarcoma of Soft Tissue;   Epithelioid Malignant Peripheral Nerve Sheath Tumor;   Epithelioid Sarcoma;   Extraskeletal Myxoid Chondrosarcoma;   Extraskeletal Osteosarcoma;   Fibrohistiocytic Neoplasm;   Glomus Tumor of the Skin;   Inflammatory Myofibroblastic Tumor;   Intimal Sarcoma;   Leiomyosarcoma...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Adult Alveolar Soft Part Sarcoma;   Adult Angiosarcoma;   Adult Epithelioid Sarcoma;   Adult Extraskeletal Myxoid Chondrosarcoma;   Adult Extraskeletal Osteosarcoma;   Adult Fibrosarcoma;   Adult Leiomyosarcoma;   Adult Liposarcoma;   Adult Malignant Mesenchymoma;   Adult Synovial Sarcoma;   Adult Unclassified Pleomorphic Sarcoma;   Childhood Alveolar Soft Part Sarcoma;   Childhood Angiosarcoma;   Childhood&...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Adult Alveolar Soft-part Sarcoma;   Adult Angiosarcoma;   Adult Desmoplastic Small Round Cell Tumor;   Adult Epithelioid Hemangioendothelioma;   Adult Epithelioid Sarcoma;   Adult Extraskeletal Chondrosarcoma;   Adult Extraskeletal Osteosarcoma;   Adult Fibrosarcoma;   Adult Leiomyosarcoma;   Adult Liposarcoma;   Adult Malignant Fibrous Histiocytoma;   Adult Malignant Hemangiopericytoma;   Adult Malignant Mesench...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Adult Alveolar Soft Part Sarcoma;   Adult Angiosarcoma;   Adult Desmoplastic Small Round Cell Tumor;   Adult Epithelioid Hemangioendothelioma;   Adult Epithelioid Sarcoma;   Adult Extraskeletal Myxoid Chondrosarcoma;   Adult Extraskeletal Osteosarcoma;   Adult Fibrosarcoma;   Adult Leiomyosarcoma;   Adult Liposarcoma;   Adult Malignant Mesenchymoma;   Adult Malignant Peripheral Nerve Sheath Tumor;   Adu...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Adult Angiosarcoma;   Adult Desmoplastic Small Round Cell Tumor;   Adult Epithelioid Sarcoma;   Adult Extraskeletal Myxoid Chondrosarcoma;   Adult Extraskeletal Osteosarcoma;   Adult Fibrosarcoma;   Adult Leiomyosarcoma;   Adult Liposarcoma;   Adult Malignant Mesenchymoma;   Adult Malignant Peripheral Nerve Sheath Tumor;   Adult Rhabdomyosarcoma;   Adult Synovial Sarcoma;   Adult Unclassified Pleomorphic&nbs...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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