Fluorescence of the tri-cyclic adenine and isoguanine derivatives and their ribosides: possible analytical applications.

Fluorescence of the tri-cyclic adenine and isoguanine derivatives and their ribosides: possible analytical applications.
Acta Biochim Pol. 2019 Dec 05;:
Authors: Stachelska-Wierzchowska A, Wierzchowski J
Abstract
Fluorescent tri-cyclic purine analogs, derivatives of isoguanine and adenine, were examined as potential substrates of purine-nucleoside phosphorylase. It was found previously that etheno- derivatives of both compounds are ribosylated in phosphate-free media, but ribosylation places in some instances differ from purine N9. New ribosides are examined as potential substrates of human blood PNP and indicators of this enzyme. Of these, N6-riboside of 1,N6-etheno-adenine was found the most promising.
PMID: 31804790 [PubMed - as supplied by publisher]

Source: Acta Biochim Pol - December 4, 2019 Category: Biochemistry Authors: Stachelska-Wierzchowska A, Wierzchowski J Tags: Acta Biochim Pol Source Type: research