A Review of CSF and Serum Biomarkers to Stratify Acute Spinal Cord Injury Based on Severity of Injury and Prognosis

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Source: Contemporary Spine Surgery - Category: Orthopaedics Tags: CME Quiz Source Type: research

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ConclusionsDespite published reports showing benefit for pain control in patients with BPA, the overall low quality, retrospective evidence included in this review highlights the need for a rigorous prospective study to further address this indication.
Source: Neuromodulation: Technology at the Neural Interface - Category: Biotechnology Authors: Tags: Review Article Source Type: research
Ventilators are used by patients who lose lung function due to complications from a variety of diseases such as spinal cord injuries, COPD, stroke, pneumonia, and ALS. In addition to dealing with a debilitating situation, patients tend to be hooked t...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiology Critical Care Exclusive Medicine Pediatrics Rehab Source Type: blogs
Central neuropathic pain (CNP) after spinal cord injury (SCI) is debilitating and immensely impacts the individual. Central neuropathic pain is relatively resistant to treatment administered after it develops, perhaps owing to irreversible pathological processes. Although preemptive treatment may overcome this shortcoming, its administration necessitates screening patients with clinically relevant biomarkers that could predict CNP early post-SCI. The aim was to search for such biomarkers by measuring pronociceptive and for the first time, antinociceptive indices early post-SCI. Participants were 47 patients with acute SCI ...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Conclusions: The results disclosed the protective impacts of PA on PC12 cells to resist H2O2-provoked damage. MEG3, Wnt/β-catenin and PTEN/PI3K/AKT pathways joined in adjusting the activity of PA in H2O2-damaged PC12 cells. PMID: 32064936 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Poliomyelitis is a motor neuron disease of the anterior horn of the spinal cord. It leads to asymmetrical flaccid paralysis and muscle atrophy that reduces the patient's stability and mobility and alters the gait pattern, predisposing to falls. Until the massive clinical application of vaccines, it was quite prevalent in some countries in the 50s and, the people who suffered the epidemic during childhood is nowadays more than 65 years old, constituting a risk groups for traumatological pathology.
Source: Injury - Category: Orthopaedics Authors: Source Type: research
In this study, we report the accumulation of tissue-resident ILC2 in the choroid plexus of the aged brain, with ILC2 comprising a major subset of lymphocytes in the choroid plexus of aged mice and humans. ILC2 in the aged brain are long-lived and capable of reversibly switching between cell cycle dormancy and proliferation. They are relatively resistant to cellular senescence and exhaustion under replication stress, leading to enhanced self-renewal capability. They are functionally quiescent at homeostasis but can be activated by exogenous IL-33 to produce large amounts of IL-5 and IL-13 as well as a variety of other effec...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Conditions:   Spinal Cord Injuries;   Injury, Brain, Traumatic Intervention:   Other: standard of care for patient with brain trauma and spinal cord injury Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report a patient with unusual occipital neuropathic pain (at-level neuropathic pain) due to a small central cervical spinal cord injury (SCI).
Source: BMC Neurology - Category: Neurology Authors: Tags: Case report Source Type: research
Spinal cord injury (SCI) is a highly debilitating pathology without curative treatment. One of the most promising disease modifying strategies consists in the implantation of stem cells to reduce inflammation ...
Source: Journal of Biomedical Science - Category: Biomedical Science Authors: Tags: Research Source Type: research
Spinal Cord, Published online: 18 February 2020; doi:10.1038/s41393-020-0435-5Clinical decision-making on spinal cord injury-associated pneumonia: a nationwide survey in Germany
Source: Spinal Cord - Category: Research Authors: Source Type: research
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