Urinary metabolomics predict the severity of overactive bladder syndrome in an aging female population

ConclusionsAltogether, these findings establish that urinary metabolites of mitochondrial dysfunction, ketosis and oxidative stress can be potential biomarkers of OAB severity and diagnosis.
Source: International Urogynecology Journal - Category: OBGYN Source Type: research

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ConclusionsThere is a temptation to label OAB as “idiopathic” without obvious causation, given the poorly understood nature of its pathophysiology. OAB should be seen as a complex, multifactorial symptom syndrome, resulting from multiple potential pathophysiological mechanisms. Identification of the underlying causes on an individual basis may lead to the definition of OAB phenotypes, paving the way for personalised medical care.Patient summaryOveractive bladder (OAB) is a storage symptom syndrome with multiple possible causes. Identification of the mechanisms causing a patient to experience OAB symptoms may he...
Source: European Urology - Category: Urology & Nephrology Source Type: research
ConclusionThe main results showed protective cardiovascular effects of mirabegron, making ß3-adrenergic receptor activation a promising option to consider during metabolic syndrome.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Increased abdominal visceral fat leads to excessive production of various inflammatory cytokines, inducing chronic systemic inflammations and metabolic syndrome (MetS). Although the spread of systemic inflammation due to such MetS is the cause of various lifestyle diseases, MetS has been reported recently to be an important factor that affects urinary symptoms, including overactive bladder (OAB). However, no study has elucidated the relationship between excessive visceral fat volume and the OAB morbidity and severity.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Urodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Non-neurogenic Voiding Dysfunction II Source Type: research
Overactive bladder syndrome (OAB) shows increasing prevalence with aging. OAB is found in association with metabolic syndrome, yet the mechanism is not clear. Urine metabolome is a useful tool to diagnose metabolic alterations which may, by local effect, affect bladder physiology. The aim of this study is to identify specific metabolic markers of OAB using urine metabolomics of an aging female population.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Urodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Basic Research & Pathophysiology II Source Type: research
AbstractPurpose of ReviewTo review recent data on the prevalence and treatment of the symptom of urgency in men with benign prostatic enlargement (BPE).Recent FindingsIn recent years, researchers have moved to separate out individual lower urinary tract symptoms (LUTS) to see the individual impact. A recent registry trial put the prevalence of urgency at 38% in men with BPE. Other studies have reported urgency present in 64% of men with LUTS. While urgency is not as frequent a complaint in BPE as nocturia and frequency, it does have an impact on health-related quality of life. It is not increased in men with diabetes or th...
Source: Current Bladder Dysfunction Reports - Category: Urology & Nephrology Source Type: research
Conclusion Our study demonstrates a correlation between obesity and OAB/DO in female patients. However, other components of MetS do not appear to be associated with either OAB and DO. Weight reduction should be strongly recommended in women with OAB.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Authors: Saratlija Novakovic Z, Tesija RA, Puljak L Abstract OBJECTIVE: The aim of this case-control study was to investigate the association between overactive bladder (OAB) and metabolic syndrome (MetS). The primary hypothesis was that OAB is significantly more prevalent among patients with MetS than in control participants. MATERIALS AND METHODS: A case-control study was conducted among 114 patients, with 57 patients in the MetS group and 57 in the control group. Study participants were recruited in a family medicine practice. They filled out a questionnaire including questions on age, gender, clinical sympt...
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
Conclusion: Our findings support the theory that possible sympathetic overactivity, proinflammatory status, oxidative stress and other pathological conditions associated with MetS and potentially involved in the development of OAB lead to increased serum NGF levels. These findings may help to shed light on the complicated pathogenesis of OAB.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - Category: OBGYN Source Type: research
This study aimed to determine if GPR91, the succinate receptor, is expressed and functional in the bladder. Urothelial and smooth muscle cells (SMCs) were cultured and characterized. PCR revealed that urothelial cells express GPR91, twice as much as SMCs. Incubation of cells with succinate stimulated phosphorylation of ERK and JNK in urothelial cells. Succinate also potently inhibited forskolin-stimulated cyclic AMP production in urothelial cells. ERK phosphorylation stimulated by succinate was abolished by inhibitors of MAPK pathway, phospholipase C and PKC. Incubation of urothelial cells with succinate potently increased...
Source: Cellular Signalling - Category: Cytology Authors: Tags: Cell Signal Source Type: research
Abstract Traditionally, lower urinary tract dysfunction was attributed to poor viscoelasticity of the bladder, neurogenic causes, and the enlarged prostate. The etiology of lower urinary tract symptoms (LUTS) extends well beyond prostate enlargement and bladder outlet obstruction. There are many publications of the impact of obesity on diverse urological conditions, malignant and nonmalignant, in terms of patient clinicopathological parameters and outcomes. The literature is characterized by often conflicting results. However, there is increasing evidence showing that metabolic syndrome and, in particular, obesity...
Source: Current Bladder Dysfunction Reports - Category: Urology & Nephrology Source Type: research
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