Thirst in Patients With Heart Failure in Sweden, the Netherlands, and Japan
Conclusions: Thirst in patients with HF was related to a higher dose of loop diuretics and fluid restriction. Healthcare providers should realize that it is important to assess thirst regularly and reconsider the need of a fluid restriction and the amount of loop diuretics in case of thirst.
Conclusions: Approximately, one-fourth of patients developed hyperkalaemia during follow-up which was associated with a lower MRA dose during follow-up. Discontinuation of MRA, but not hyperkalaemia itself, was associated with an increased risk of all-cause mortality and heart failure admission in HFrEF patients. PMID: 32264757 [PubMed - as supplied by publisher]
Conclusions/interpretationOur study provides the first evidence thatAkap1 deficiency exacerbates diabetic cardiomyopathy by impeding mitochondrial translocation of NDUFS1 to induce mitochondrial dysfunction and cardiomyocyte apoptosis. Our findings suggest thatAkap1 upregulation has therapeutic potential for myocardial injury in individuals with diabetes.
Publication date: Available online 8 April 2020Source: JACC: Heart FailureAuthor(s): Sebhat Erqou, Lan Jiang, Gaurav Choudhary, Michelle Lally, Gerald S. Bloomfield, Andrew R. Zullo, Theresa I. Shireman, Mathew Freiberg, Amy C. Justice, James Rudolph, Nina Lin, Wen-Chih Wu
Publication date: Available online 8 April 2020Source: JACC: Heart FailureAuthor(s): Douglas L. Mann
Publication date: Available online 8 April 2020Source: JACC: Heart FailureAuthor(s): Sameer Prasada, Adovich Rivera, Arvind Nishtala, Anna E. Pawlowski, Arjun Sinha, Joshua D. Bundy, Simran A. Chadha, Faraz S. Ahmad, Sadiya S. Khan, Chad Achenbach, Frank J. Palella, Rosalind Ramsey-Goldman, Yvonne C. Lee, Jonathan I. Silverberg, Babafemi O. Taiwo, Sanjiv J. Shah, Donald M. Lloyd-Jones, Matthew J. Feinstein
Publication date: Available online 8 April 2020Source: JACC: Heart FailureAuthor(s): Mona Fiuzat, Naomi Lowy, Norman Stockbridge, Marco Sbolli, Federica Latta, JoAnn Lindenfeld, Eldrin F. Lewis, William T. Abraham, John Teerlink, Mary Walsh, Paul Heidenreich, Biykem Bozkurt, Randall C. Starling, Scott Solomon, G. Michael Felker, Javed Butler, Clyde Yancy, Lynne W. Stevenson, Christopher O'Connor, Ellis Unger
This study investigated the effects of Chinese herbal formula B307 on thyroidectomy-induced cardiopulmonary exercise dysfunction in rats. Twenty male rats were equally divided into four groups: negative control with sham treatment, positive control with oral B307 treatment only, thyroidectomy treatment only, and thyroidectomy with B307 posttreatment groups. The feeding dose of B307 was 50 mg/kg per day for 14 days. We examined and then compared the thyroid-stimulating hormone (TSH), free triiodothyronine (T3), free thyroxine (T4), and reactive oxygen species (ROS) from the blood of these four groups. Also, we compar...
Publication date: Available online 7 April 2020Source: JACC: Heart FailureAuthor(s): Nianguo Dong, Jie Cai, Ying Zhou, Junwei Liu, Fei Li
Exercise stress echocardiography (ESE) is a valuable diagnostic and prognostic tool in adults with hypertrophic cardiomyopathy (HCM). Inducible and resting left ventricular outflow tract gradients are important predictors of heart failure. However, there are minimal data on the utility of this modality in children.
Sacubitril/valsartan was shown to be superior to enalapril in the Prospective Comparison of angiotensin receptor neprilysin inhibitor with an angiotensin converting enzyme inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) study. However, the study design raised uncertainty about the potential real-world tolerability amongst less well selected cohorts. We aimed to examine the real-world tolerability and factors associated with successful titration of sacubitril/valsartan.