Differential antiseizure medication sensitivity of the Affective Reactivity Index: A randomized controlled trial in new-onset pediatric focal epilepsy

ConclusionBoth child and parent/guardian versions of the ARI appear sensitive to medication-induced irritability associated with LEV on both the group and individual levels. The findings extend the applicability of ARI from characterizing the presence of clinical irritability as a psychiatric diagnostic feature to a more modifiable aspect of behavior change related to medication management and support its use in clinical trial applications.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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SUMMARY: Deep brain stimulation is an established therapy for multiple brain disorders, with rapidly expanding potential indications. Neuroimaging has advanced the field of deep brain stimulation through improvements in delineation of anatomy, and, more recently, application of brain connectomics. Older lesion-derived, localizationist theories of these conditions have evolved to newer, network-based "circuitopathies," aided by the ability to directly assess these brain circuits in vivo through the use of advanced neuroimaging techniques, such as diffusion tractography and fMRI. In this review, we use a combinatio...
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: ADULT BRAIN Source Type: research
A 53-year-old woman with a history of chronic obstructive pulmonary disease, epilepsy, hypertension, and alcohol abuse presented after getting a burn injury on her lap from spilling boiled water. She reported 3 vodka drinks daily. Her medications included valproic acid, sertraline, isosorbide mononitrate, omeprazole, and loratadine. Her blood pressure was 133/84 mm  Hg, and her pulse was 98/min. On physical examination she was drowsy but followed commands and had moist mucus membranes, jugular venous pressure of 6 cm of H2O, clear bilateral airway movement, and no pedal edema.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
In conclusion, sitting for prolonged periods of time without interruption is unfavorably associated with DBP and HDL cholesterol. Exercise Slows Inappropriate Growth of Blood Vessels in a Mouse Model of Macular Degeneration https://www.fightaging.org/archives/2020/07/exercise-slows-inappropriate-growth-of-blood-vessels-in-a-mouse-model-of-macular-degeneration/ Excessive growth of blood vessels beneath the retina is a proximate cause of blindness in conditions such as macular degeneration. Researchers here provide evidence for physical activity to be influential in the pace at which this process of tissue...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
It was a great honor to receive hundreds of questions before the live Q&A we recently had. There were in fact so many that I’ve decided I would share some of them here. These questions represent an ample mix of interests, covering a wide range of issues from A.I. to the future of medical education. And worry not if you haven’t gotten your question answered just yet: in the coming weeks we’ll also be writing articles that are based on some of the most intriguing questions. Re-watch the event on YouTube: #1 On The Relationship Of Doctors And Patients What sort of strategies can we use...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: 3D Printing Artificial Intelligence Digital Health Research E-Patients Future of Medicine Future of Pharma Healthcare Design Robotics Security & Privacy Telemedicine & Smartphones AI Hospital Medical education technology wearab Source Type: blogs
Publication date: October 2020Source: Epilepsy &Behavior, Volume 111Author(s): Ali Akbar Mohammadi, Abdolkhalegh Keshavarzi, Amirhossein Erfani, Mahboobeh-Sadat Modarresi, Reza Shahriarirad, Keivan Ranjbar
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Abstract OBJECTIVE: Few studies have examined seizures, accidental injuries at work, and reasons for resignation in people with epilepsy (PWE). We performed a questionnaire survey of PWE to identify the risk of injury at work, its relationship to different seizure characteristics, and reasons for resignation. METHODS: We distributed a questionnaire survey in the outpatient clinic of a single epilepsy center. Medical information was obtained retrospectively from medical records. RESULTS: Of 200 patients who received the questionnaire, 172 responded. Two-fifths of PWE had experienced seizures at work, but ...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
Abstract PURPOSE: Based on the high rates of burn injuries in patients with epilepsy, it is crucial to evaluate the epidemiological factors, etiology, types of burns, and outcome of these certain individuals and to enhance knowledge about the possible risks of epilepsy-related burns by preventive actions and programs. METHOD: Our retrospective study was carried out from September 2013 to February 2017 in Amir-al Momenin Hospital, a tertiary referral burns and plastic surgery healthcare center. Because of the fact that a number of patients with burns had experienced their trauma at the time of convulsion or in...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
Epilepsy is a common and relatively treatable condition; about two thirds of people with it can have their seizures reduced using available medicines which are usually not excessively expensive[1]. When seizures continue, particularly if they are convulsive, people with epilepsy (PWE) are exposed to significant risks. They are up to six times more likely to die prematurely than people without epilepsy[2,3]. Burns and fractures are much more common. And very importantly, they, and their families, are subject to significant social stigma from the communities in which they live[4]; this may affect many factors in their lives ...
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
Publication date: May 2020Source: Journal of the American College of Radiology, Volume 17, Issue 5, SupplementAuthor(s): Expert Panel on Neurological Imaging, Ryan K. Lee, Judah Burns, Amna A. Ajam, Joshua S. Broder, Santanu Chakraborty, Suzanne T. Chong, A. Tuba Kendi, Luke N. Ledbetter, David S. Liebeskind, Jeffrey S. Pannell, Jeffrey M. Pollock, Joshua M. Rosenow, Matthew D. Shaines, Robert Y. Shih, Konstantin Slavin, Pallavi S. Utukuri, Amanda S. Corey
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
Seizures and epilepsy are a set of conditions that can be challenging to diagnose, treat, and manage. This document summarizes recommendations for imaging in different clinical scenarios for a patient presenting with seizures and epilepsy. MRI of the brain is usually appropriate for each clinical scenario described with the exception of known seizures and unchanged semiology (Variant 3). In this scenario, it is unclear if any imaging would provide a benefit to patients. In the emergent situation, a noncontrast CT of the head is also usually appropriate as it can diagnose or exclude emergent findings quickly and is an alter...
Source: Journal of the American College of Radiology : JACR - Category: Radiology Authors: Tags: Appropriate use criteria Source Type: research
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