Medtech in a Minute: Dexcom 's Snafu, a VR Surgical Robot, and More

Dexcom Learns a Valuable Lesson  A major server outage rattled Dexcom customers – particularly parents of diabetic children – over the U.S. Thanksgiving holiday weekend. But most were not as mad about the technology glitch as they were about the company's lack of communication about the issue. Dexcom has since fixed the problem and promised to communicate better with customers going forward.   Vicarious Surgical Scores Breakthrough Designation for Surgical Robot Vicarious Surgical is now the first to receive a breakthrough device designation from FDA for a robotically-assisted surgical device. What makes this new robot so special? Virtual reality. ViewRay Inks Deals with Elekta and Medtronic ViewRay has signed a non-binding memorandum of understanding with both Elekta and Medtronic. Elekta has committed to invest capital for up to a 9.9% minority interest in ViewRay, and Medtronic has agreed to invest in a minority interest in the company. ViewRay and Elekta plan to advance the knowledge and use of MR-guided radiation therapy. ViewRay and Medtronic plan to explore the clinical benefits of the MRIdian MR-guided radiation therapy system.
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news

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sin Okada Yamada Dapagliflozin, empagliflozin, tofogliflozin, selective inhibitors of sodium-glucose cotransporter 2 (SGLT2), is used clinically to reduce circulation glucose levels in patients with type 2 diabetes mellitus by blocking the reabsorption of glucose by the kidneys. Dapagliflozin is metabolized and inactivated by UGT1A9. Empagliflozin is metabolized and inactivated by UGT1A9 and by other related isoforms UGT2B7, UGT1A3, and UGT1A8. Tofogliflozin is metabolized and inactivated by five different enzymes CYP2C18, CYP3A4, CYP3A5, CYP4A11, and CYP4F3. Dapagliflozin treatment of HCT116 cells, which express...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
75 years old patient, with controlled diabetes and hypertension, very fit. he underwent in 2009, a radical prostatectomy followed 30 fractions of adjuvant 3D conformal radiation therapy to the prostatic bed only. in 2018: PSA rise to 2.16 2019: PSA 2.16 Pet PSMA showed a 7 mm LN at the level of L4-5 secondary lesion, with no recurrence in the tumor bed, neither in bone or other LNs. He was put on decapeptyl + casodex. please vote the poll
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): Dalal Alhajji, Yoon Ah Danskin, Bridget O'hara, Karl Armand Solano, Jessica Flynn, Elyn Riedel, Sae Hee Kim Yom, Cherry EstiloObjectivesOsteoradionecrosis (ORN) is a complication of head and neck radiation therapy (RT) and is associated with significant morbidity. The incidence of ORN is variable, and it has been speculated to be lower with advanced RT techniques. Risk factors that have been associated with the development of ORN mainly include trauma and a radiation dose to the head and neck ...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
A male patient, 72 years of age and white, complained of "bubbles in the mouth for 10 days." Past medical history: Received renal transplant (2001), diabetes mellitus, coronary artery bypass graft, and radiation therapy for basal cell carcinoma in the head region (2014). Extraoral examination showed basal cell carcinomas in the right and left ears and blood lesions in the arms. At intraoral examination, we observed hemorrhagic blister and ulcerated lesion with superficial shallow edges, preceded by blister both in the lower lip mucosa, blood injury, slightly high edges, blackish coloration, and located in the mucosa of the cheek.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
This study shows that CA are released from periventricular and subpial regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Summary: Chronic radiation-induced osteomyelitis/necrosis of the rib was rarely encountered in breast cancer patients even before the era of breast-conserving therapy. Few studies have focused on how to evaluate the extent of rib osteomyelitis for surgical management. A 78-year-old woman who had received radiation therapy after a radical mastectomy due to breast cancer 30 years ago manifested a rib pain and chest skin ulcers. Because chest magnetic resonance imaging failed to visualize osteomyelitis of the rib, a wide-ranged rib resection was initially planned considering her radiation field. An additional imaging, 3-dim...
Source: Plastic and Reconstructive Surgery Global Open - Category: Cosmetic Surgery Tags: Case Report Source Type: research
We describe the presentation, management, and outcomes of patients with PM. SUBJECTS, MATERIALS, AND METHODS: We performed a retrospective review of patients diagnosed with PM at a single institution from 1996 to 2015. Eighty-five patients diagnosed with metastasis to the pituitary or sella turcica by pathology or based on a combination of neuroimaging and clinical findings were included. Univariate and multivariable Cox regressions evaluated associations between clinical factors and overall survival. RESULTS: The most frequent sites of primary malignancies resulting in PM were lung (26%) and breast (26%). Median...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
ConclusionsThis case report demonstrates an unusual etiology of back and leg pain in a young man and elucidates the palliative effects of radiation therapy for epithelioid hemangioma involving the lumbar spine.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
AbstractBackgroundThe android:gynoid percent fat ratio (AGFR) is associated with increased risk of cardiovascular disease and type 2 diabetes in breast cancer survivors (BCS). Exercise reduces fat mass in BCS; however, few studies have focused on AGFR. The study purpose was to examine the effects of a 16-week aerobic and resistance exercise intervention on AGFR among BCS. We assessed whether exercise-induced changes in AGFR were associated with improved insulin resistance.MethodsBCS (Stage I-III) were randomized to exercise (n  = 50) or usual care (n = 50). The thrice weekly 16-week intervention...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsThis is the first study to report acute toxicities of combining pembrolizumab with radiation in LA-HNSCC. Pembrolizumab does not potentiate typical XRT associated toxicities and no unexpected immune related adverse events were observed. Further, lower rates of feeding tube placement and grade 3/4 dermatitis, xerostomia, and mucositis were noted when compared to RTOG1016 (concurrent XRT with cisplatin or cetuximab in LA-HNSCC).Clinical trial identificationNCT02609503.Legal entity responsible for the studyThe authors.FundingMerck Sharp&Dohme Corp.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
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