Should Urine-LAM Tests Be Used in TB Symptomatic HIV-Positive Patients When No CD4 Count Is Available? A Prospective Observational Cohort Study From Malawi

Background: Current eligibility criteria for urine lateral-flow lipoarabinomannan assay (LF-LAM) in ambulatory, HIV-positive patients rely on the CD4 count. We investigated the diagnostic yield of LF-LAM and the 6-month mortality in ambulatory, TB symptomatic, HIV-positive patients regardless of their CD4 count. Methods: We conducted a prospective, observational study that included all ambulatory, ≥15-year-old, TB symptomatic (cough, weight loss, fever, or night sweats) HIV-positive patients presenting at 4 health facilities in Malawi. Patients received a clinical examination and were requested urine LF-LAM, sputum microscopy, and Xpert MTB/RIF. TB was defined as bacteriologically confirmed if Xpert was positive. Results: Of 485 patients included, 171 (35.3%) had a CD4
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Implementation Science Source Type: research

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Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Pulmonary disease remains the most significant determinant of morbidity and mortality in cystic fibrosis (CF). Patients with CF typically experience progressive decline in lung function punctuated by pulmonary exacerbations [1], acute episodes characterized by worsened cough and sputum production and thickness, as well as decreases in pulmonary function, appetite, and weight. Over 34% of patients with CF are treated with IV antibiotics for an exacerbation each year [2]; median duration of hospitalization for these events is 9.3 days, and the median duration of IV antibiotics is 13 days [2].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
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ConclusionIt is envisaged that the current review will add value to more scientific research on M. flabellifolius and enhance/promote the increased interest in the sustainable commercialization of M. flabellifolius herbal tea as well as lead to the validation of unverified ethnobotanical claims.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsAn advanced 3-D printing model provides affirmative information related to treatment strategy and is also a prospective tool for better doctor –patient communication regarding the disease.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Condition:   Post-infectious Cough Interventions:   Drug: PREDNISON Galepharm Tabl. 20 mg;   Drug: placebo tablets Sponsors:   University Hospital, Basel, Switzerland;   Swiss National Science Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Asthma Intervention:   Sponsor:   McMaster University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
ConclusionsThe SAPB, as part of a multimodal analgesia regimen, is non ‐inferior in terms of 48‐hour opioid consumption compared to SPVB and is associated with improved functional measures in thoracic surgical patients.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
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