IgG4 is Elevated in Eosinophilic Esophagitis but Not in Gastroesophageal Reflux Disease Patients

Background: For eosinophilic esophagitis (EoE) recently an association with immunoglobulin (Ig)G4 rather than IgE has been reported. Gastroesophageal reflux disease (GERD) is the most important differential diagnosis of EoE. We compared esophageal IgG4 plasma cell infiltration and serum IgG4 levels of EoE patients (before and after budesonide therapy) with GERD patients. Methods: Prospectively collected serum samples of 17 EoE patients before and after 8 weeks of therapy with budesonide (1 mg BID) were analyzed for total and antigen-specific IgG4 and IgE levels. Also, immunohistochemical analysis of total and IgG4-positive plasma cells was performed on esophageal biopsies of these patients. In total, 14 GERD patients without histologic proof of eosinophilic infiltration were taken as a control group. Results: Total IgG4 serum levels in EoE patients were significantly higher than in GERD patients (121.0 vs. 71.2 mg/dL; P=0.038) and decreased under budesonide therapy (121.0 vs. 104.2 mg/dL; P=0.019). IgE levels did not differ significantly between all groups. In EoE patients also a high number of esophageal IgG4-positive plasma cells was detected and significantly reduced under therapy (29.1 vs. 0.1 IgG4-positive cells; P
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

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AbstractPurposeGastroesophageal reflux disease (GERD) is reported as one of the symptoms of adult spinal deformity (ASD). Little is known about the mid- to long-term improvement in GERD symptoms after ASD surgery. Therefore, this retrospective study from prospectively collected database aimed to investigate GERD symptoms in patients for a minimum of 2  years after ASD corrective surgery.MethodsRecords from 230 patients (mean age: 64  years) who underwent ASD surgery were examined using the frequency scale for the symptoms of GERD (FSSG) questionnaires for the diagnosis of GERD. FSSG scores and radiographic parame...
Source: European Spine Journal - Category: Orthopaedics Source Type: research
ConclusionsIn patients with PPI-refractory nonerosive reflux disease, salivary pepsin measurement may help diagnose patients who have conclusive evidence of reflux, whereas it is not adequate for identifying patients with APE.
Source: Esophagus - Category: Gastroenterology Source Type: research
(Natural News) Gastrointestinal (GI) problems have always been a common occurrence in many patients with autism, yet the mechanisms behind this phenomenon are not fully understood. Studies have shown that around 70 percent of people with autism spectrum disorder (ASD) have a variant of gastrointestinal disorder, including gastroesophageal reflux disease (GERD) and gastritis. If left...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
CONCLUSION: In patients with heartburn and regurgitation symptoms, the prevalence of dysphagia was at least 48%, and has a positive correlation with the overall symptoms of gastroesophageal reflux.
Source: Clinics - Category: General Medicine Source Type: research
Graft-versus-host disease (GVHD) is a major complicating factor in determining morbidity and mortality following allogeneic stem cell transplant. To prevent GVHD, our institution administers calcineurin inhibitors and low doses of methotrexate (MTX) (5-15 mg/m2) on days +1, +3, +6, +11 for GVHD prophylaxis.Proton pump inhibitors (PPIs) are used for the treatment of gastroesophageal reflux disease, pyrosis, and/or peptic ulcer disease. PPIs have been shown to inhibit the ATP-binding cassette drug transporter Breast Cancer Resistance Protein's (BCRP/ABCG2) ability to excrete methotrexate into the urine in a concentration-dependent manner.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 252 Source Type: research
Conclusions: Overall, gastrostomy placement was not associated with an increase in acid exposure on 24-hour multichannel intraluminal impedance pH monitoring. Similarly, the prevalence of gastro-oesophageal reflux-related symptoms did not change after gastrostomy.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research
b Sarmidi Herbal plants are traditionally utilized to treat various illnesses. They contain phytochemicals that can be extracted using conventional methods such as maceration, soxhlet, and boiling, as well as non-conventional methods including ultrasonic, microwave, and others. Carica papaya leaves have been used for the treatment of dengue, fungal, and bacterial infections as well as an ingredient in anti-aging products. Phytochemicals analysis detected the presence of kaempferol, myricetin, carpaine, pseudocarpaine, dehydrocarpaine I and II, ferulic acid, caffeic acid, chlorogenic acid, β-carotene, lycope...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Condition:   Gastroesophageal Reflux Intervention:   Procedure: Laparoscopic sleeve gastrectomy Sponsor:   Chinese University of Hong Kong Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study explicates the preparation of ethyl acetate (EtOAc) via esterification of acetic acid and ethanol over brønsted acid ionic liquid (1-Butyl-3-methylimidazolium hydrogen sulfate, [BMIM]HSO4) as catalyst. The ideal homogeneous (IH) and non-ideal homogeneous (NIH) models were applied to describe reaction kinetics and the model parameters were obtained by data fitting, where NIH model showed higher accuracy and confirmed the higher catalytic efficiency of [BMIM]HSO4 than Amberlyst 15. A novel reactive distillation (RD) flow-sheet for EtOAc production using [BMIM]HSO4 was designed and performed by Aspen Plus, i...
Source: Chemical Engineering Research and Design - Category: Chemistry Source Type: research
Bioelectronic medicine could be one of healthcare’s biggest secrets. The space is filled with applications – but many aren’t mainstream yet. A panel titled “ Bioelectronic Medicine: Redefining Medical Treatment,” will be held Tuesday, February 11, from 2:05 to 3:00 p.m. in Room 210A at MD&M West Anaheim to discuss the space and how it could impact healthcare. While there have been some significant movements in that time – perhaps one of the greatest has developments has been GlaxoSmithKline teaming up with Verily Lif...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Electronics Source Type: news
More News: Acid Reflux | Gastroenterology | Gastroesophageal Reflux Disease | GERD