Cancers, Vol. 11, Pages 1968: The Chalcone Lonchocarpin Inhibits Wnt/ β-Catenin Signaling and Suppresses Colorectal Cancer Proliferation

Cancers, Vol. 11, Pages 1968: The Chalcone Lonchocarpin Inhibits Wnt/β-Catenin Signaling and Suppresses Colorectal Cancer Proliferation Cancers doi: 10.3390/cancers11121968 Authors: Danilo Predes Luiz F. S. Oliveira Laís S. S. Ferreira Lorena A. Maia João M. A. Delou Anderson Faletti Igor Oliveira Nathalia G. Amado Alice H. Reis Carlos A. M. Fraga Ricardo Kuster Fabio A. Mendes Helena L. Borges Jose G. Abreu The deregulation of the Wnt/β-catenin signaling pathway is a central event in colorectal cancer progression, thus a promising target for drug development. Many natural compounds, such as flavonoids, have been described as Wnt/β-catenin inhibitors and consequently modulate important biological processes like inflammation, redox balance, cancer promotion and progress, as well as cancer cell death. In this context, we identified the chalcone lonchocarpin isolated from Lonchocarpus sericeus as a Wnt/β-catenin pathway inhibitor, both in vitro and in vivo. Lonchocarpin impairs β-catenin nuclear localization and also inhibits the constitutively active form of TCF4, dnTCF4-VP16. Xenopus laevis embryology assays suggest that lonchocarpin acts at the transcriptional level. Additionally, we described lonchocarpin inhibitory effects on cell migration and cell proliferation on HCT116, SW480, and DLD-1 colorectal cancer cell lines, without any detectable effects on the non-tumoral intestinal cell l...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research