Cancers, Vol. 11, Pages 1969: Imaging and Tissue Biomarkers of Choline Metabolism in Diffuse Adult Glioma: 18F-Fluoromethylcholine PET/CT, Magnetic Resonance Spectroscopy, and Choline Kinase α
Cancers, Vol. 11, Pages 1969: Imaging and Tissue Biomarkers of Choline Metabolism in Diffuse Adult Glioma: 18F-Fluoromethylcholine PET/CT, Magnetic Resonance Spectroscopy, and Choline Kinase α
Cancers doi: 10.3390/cancers11121969
Authors:
Matthew Grech-Sollars
Katherine L Ordidge
Babar Vaqas
Claire Davies
Vijay Vaja
Lesley Honeyfield
Sophie Camp
David Towey
Helen Mayers
David Peterson
Kevin O’Neill
Federico Roncaroli
Tara D Barwick
Adam D Waldman
The cellular and molecular basis of choline uptake on PET imaging and MRS-visible choline-containing compounds is not well understood. Choline kinase alpha (ChoKα) is an enzyme that phosphorylates choline, an essential step in membrane synthesis. We investigate choline metabolism through 18F-fluoromethylcholine (18F-FMC) PET, MRS, and tissue ChoKα in human glioma. Fourteen patients with a suspected diffuse glioma underwent multimodal 3T MRI and dynamic 18F-FMC PET/CT prior to surgery. Co-registered PET and MRI data were used to target biopsies to regions of high and low choline signal, and immunohistochemistry for ChoKα expression was performed. The 18F-FMC/PET differentiated WHO (World Health Organization) grade IV from grade II and III tumours, whereas MRS differentiated grade III/IV from grade II tumours. Tumoural 18F-FMC/PET uptake was higher than in normal-appearing white matter across all grades and markedly elevated within regions of contrast enhanc...
Source: Cancers - Category: Cancer & Oncology Authors: Matthew Grech-Sollars Katherine L Ordidge Babar Vaqas Claire Davies Vijay Vaja Lesley Honeyfield Sophie Camp David Towey Helen Mayers David Peterson Kevin O ’Neill Federico Roncaroli Tara D Barwick Adam D Waldman Tags: Article Source Type: research
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