A Case of Cutaneous Mycobacterium chelonae in Common Variable Immunodeficiency
Mycobacterium chelonae is a rare acid fast bacilli that grows rapidly when compared to other members of the Mycobacteria genus. Localized cutaneous infections (i.e. cellulitis/ abscess) are common in immunocompetent patients, but in an immune compromised host disseminated infections are more prevalent. Disseminated cutaneous manifestations most commonly present in patients who are immunosuppressed by malignancy, corticosteroid therapy, various immunomodulating drugs used in organ transplantation or secondary immunodeficiencies1.
BPA exposure may activate an immune system response linked to asthma that is passed down through generations, according to a study published in the journal ofProteome Research.Science Daily
Cyanoacrylate-based adhesives are commonly used in wound closure, but cases of contact dermatitis associated with the use of these products have been reported.Plastic and Reconstructive Surgery
This study was designed to evaluate whether helminthic infections suppress the natural development of systemic lupus erythematosus (SLE) in NZBWF1 mice. Infection of NZBWF1 SLE-prone mice with two nematodes failed to establish long-lasting settlement. However, the Hymenolepis microstoma (Hm) rodent tapeworm successfully established long-term parasitization of NZBWF1 mice and was used to evaluate the suppressive effects of helminth infection. Ten-month-old NZBWF1 mice developed symptoms including autoantibody generation, proteinuria, glomerular histopathology, and splenomegaly, but mice infected with Hm at 2 months of age...
Conclusions. Although there was no increase in Api m10 sIgG4 levels after 1 year bVIT, we did not observe relevant differences in other outcomes between patients with predominant Api m1 or Api m10 sensitization. PMID: 31939631 [PubMed - as supplied by publisher]
Most websites that provide information about probiotics are unreliable and often tout unproven health benefits, a new study finds.Reuters Health Information
The Pharmacogenomics Journal, Published online: 17 January 2020; doi:10.1038/s41397-019-0140-yPharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation
AbstractClean and fresh indoor air supports health and well-being. However, indoor air can contain pollutants that can cause a variety of symptoms and reduce well-being. Individual exposure agents can also increase the risk of certain diseases. Finns have taken major steps to improve the quality of indoor air for several decades. The primary focus of these activities has been the prevention and reduction of exposure to poor indoor air quality through guidance and regulation directing remediation of damaged buildings. Nevertheless, reported symptoms related to poor indoor air quality are common in Finland. In addition to ex...
The patient is a 17-year-old girl referred to our primary immunodeficiency consult service after the diagnosis of a complicated left deltoid abscess due to Salmonella Typhimurium. Three months earlier she had noticed a stiff lesion in the left upper arm similar to an insect sting, which was diagnosed as cellulitis and treated with oral flucloxacillin for 8 days. Two weeks later she presented with fever and a local abscess. The abscess was drained and treated with oral amoxicillin-clavulanic acid.
AbstractPurpose of ReviewThe goal of this paper is to review the major adverse cutaneous reactions that have been reported to the most commonly used biologics.Recent FindingsAnti-TNF agents and immune checkpoint inhibitors have significant, immune-mediated cutaneous manifestations that can necessitate discontinuation. Anti-TNF agents, IL-6 inhibitors, and IL-12/23 inhibitors can paradoxically cause psoriasis flares or unmask previously undiagnosed psoriasis. IL-17 inhibitors are unique in increasing risk forCandida infections. Benign injection site reactions, non-specific rash, cellulitis, and hypersensitivity reactions ar...
CONCLUSION: Adults with AD had increased cutaneous, respiratory, multiorgan, and systemic infections, which were associated with a considerable cost burden. PMID: 29273131 [PubMed - in process]