Abnormal Peyer ’s patch development and B cell gut homing drive IgA deficiency in Kabuki syndrome

Capsule Summary: A Kabuki syndrome mouse model reveals fewer and smaller Peyer ’s patches and decreased Itgb7, a gene encoding a gut homing molecule, suggesting that disruption of immune gut function contributes to the Kabuki syndrome disease phenotype.

Source: Journal of Allergy and Clinical Immunology - December 5, 2019 Category: Allergy & Immunology Authors: Genay O. Pilarowski, Tareian Cazares, Li Zhang, Joel S. Benjamin, Ke Liu, Sajjeev Jagannathan, Nadeem Mousa, Jennifer Kasten, Artem Barski, Andrew W. Lindsley, Hans T. Bjornsson Source Type: research