The noncanonical BMP signaling pathway plays an important role in club cell regeneration

Schematic representation of our results showing the critical roles of the noncanonical signaling pathway of BMPs, (BMPR1A ‐Tak1‐p38MAPK) in club cell regeneration. Naphthalene (NA) is metabolized by CYP‐2F2, which is expressed exclusively in club cells, generating cytotoxic epoxide that kills the club cells within 1.5 days after NA exposure. Under normal conditions, hyperplastic growth occurs at day 3 and the b ronchiolar epithelium is restored at day 7. We show that ablation ofBmpr1a,Tak1, orMapk14 (encoding p38 α) in club cells resulted in severe defects in regeneration and bronchiole repair in adult mice. AbstractThe bronchiole is a major site for the development of several life ‐threatening disorders including chronic obstructive pulmonary disease and lung adenocarcinomas. The bronchiolar epithelium is composed of club cells and ciliated epithelial cells, with club cells serving as progenitor cells. Presently, the identity of the cells involved in regeneration of bronchi olar epithelium and the underlying mechanisms remain incompletely understood. Here, we show that Prrx1, a homeobox transcription factor, can mark club cells in adult mice during homeostasis and regeneration. We further show that the noncanonical signaling pathway of BMPs, BMPR1A‐Tak1‐p38MAPK, pl ays a critical role in club cell regeneration. Ablation ofBmpr1a,Tak1, orMapk14 (encoding p38 α) in Prrx1+ club cells caused minimal effect on bronchiolar epithelium homeostasis, yet...
Source: Stem Cells - Category: Stem Cells Authors: Tags: TISSUE ‐SPECIFIC STEM CELLS Source Type: research

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A close relationship between HIF-1α expression and bone metastases in advanced NSCLC, a retrospective analysis. Oncotarget. 2019 Dec 17;10(66):7071-7079 Authors: Pezzuto A, Perrone G, Orlando N, Citarella F, Ciccozzi M, Scarlata S, Tonini G Abstract Background: Hypoxia-inducible factor (HIF-1) is a transcription factor produced in hypoxia condition, it is closely associated with tumor angiogenesis and metastasis. Aim: To investigate the expression of HIF-1α in relation with the presence or absence of bone metastasis. Methods A retrospective analysis was carried out on samples deriving from ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
AbstractObjectivesTo compare the differences in radiologic and pathologic features of surgically resected COPD ‐related adenocarcinomas according to the presence of emphysema.MethodsA total of 216 smokers with surgically resected lung adenocarcinoma were included in this retrospective study, and 102 patients were diagnosed with COPD. We classified COPD patients as emphysematous or non ‐emphysematous group based on the emphysema severity on CT and evaluated the differences in the CT and pathologic features between the 2 groups. The relationship between emphysema and disease‐free survival was assessed using a Kaplan‐...
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions: Robotic pulmonary resection proved to be a safe treatment for lung cancer. Longer follow-up periods are required in order to assess long-term survival.RESUMO Objetivo: Descrever morbidade, mortalidade e completude da ressec ção associadas à cirurgia robótica para o tratamento de câncer de pulmão não pequenas células no Brasil, assim como sobrevida global e sobrevida livre de doença. Métodos: Estudo retrospectivo incluindo pacientes com diagnóstico de carcinoma pulmonar de células não pequenas submetidos à ressec&cc...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
ConclusionsElderly patients with a PHA and moderate or high comorbidity scores have an increased risk of 90 ‐day mortality after a pancreaticoduodenectomy.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Schematic representation of our results showing the critical roles of the non ‐canonical signaling pathway of BMPs, (BMPR1A‐Tak1‐p38MAPK) in club cell regeneration. Naphthalene (NA) is metabolized by CYP‐2F2, which is expressed exclusively in club cells, generating cytotoxic epoxide that kills the club cells within 1.5 days after NA exposure. Under normal conditions , hyperplastic growth occurs at day 3 and the bronchiolar epithelium is restored at day 7. We show that ablation ofBmpr1a,Tak1, orMapk14 (encoding p38 α) in club cells resulted in severe defects in regeneration and bronchiole repair in adul...
Source: Stem Cells - Category: Stem Cells Authors: Tags: Tissue ‐Specific Stem Cells Source Type: research
Introduction: The relationship between lung cancer and COPD is well known. Recent clinical studies found a higher prevalence of obstructive sleep apnea (OSA) in patients suffering lung cancer. Although hypoxia has been suggested to be one of the main factors associated with lung malignancy, most studies addressing this topic have limitations due to the reduced number of patients recruited and because lung cancer has been analyzed avoiding its complexity in terms of different histotypes.Aim: to investigate the effect of different patterns of hypoxia on cells of the most prevalent histological sub-types of non-small cell lun...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
Conclusion: A COPD/emphysema based strategy for the selection of LCS candidates is feasible. The prevalence of LC in our high risk cohort was 2.31%. 64% of patients were operable, and median survival at 4 years was 94%.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
Introduction: Bronchiectasis has been classified as a comorbidity of COPD patients, associated with frequent exacerbations and severity of airflow limitation. In our study, we investigated the prevalence and characteristics of bronchiectasis in the lung cancer screening (LCS) program.Material and methods: A transversal study was performed. From 2014 until September 2018, 1005 patients were included in our LSC program. Of these, 949 had low-dose computed tomography (LDCT). The subjects met the NLST criteria (age between 55 and 75 who have a 30 pack-year smoking history and are currently smoking or have quit within the past ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
Conclusion: LC incidence in patients under LTOT appears low. Specific non surgical LC treatment could be administered in 2/3 of the patients with results comparable to non surgical patients without CRF.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
Lung cancer (LC) is a leading cause of cancer death worldwide. COPD is an independent risk factor for LC. Poly-ADP ribose polymerase (PARP)-1 and PARP-2 play crucial roles in DNA repair and cancer. Hypothesis: Expression of PARP-1 and PARP-2 may differ in tumors of LC patients with/without COPD and in mice (compared to non-tumor lungs) with experimental adenocarcinoma. Patients: Lung tumor and non-tumor specimens (thoracotomy) were obtained from LC patients with/ without COPD (two patient groups, N=9/group). Mice: Lung tumors (LP07 adenocarcinoma cells, 1 month) were harvested from lungs of wild-type BALB/C mice and non-tu...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
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