LncRNA CASC15 functions as an oncogene by sponging miR-130b-3p in bladder cancer.

CONCLUSIONS: Our study suggested a vital regulatory mechanism of CASC15 in BLCA, and the CASC15/miR-130b-3p axis might serve as a new therapeutic interventional target for BLCA patients. PMID: 31799648 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

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Teaching Point: Sigmoid diverticulitis may cause colo-vesical fistula from which intravesical protrusion of a pedunculated colonic polyp is an exceptional event that should not be regarded as a bladder cancer. Published on 2020-01-28 10:55:06
Source: Journal of the Belgian Society of Radiology - Category: Radiology Source Type: research
Many of the readers of this blog will be familiar withlithotripsy which involves the use of shock waves to disintegrate stones in the kidneys, bladder, and ureter (see:Lithotripsy). Scientists are now experimenting with the use of ultrasound to selectively kill cancer cells (see:Ultrasound selectively damages cancer cells when tuned to correct frequencies). They have called this type of treatment oncotripsy. Below is an excerpt from the article:A solid mechanics lab at Caltech first developed the theory of oncotripsy, based on the idea that cells are vulnerable to ultrasound at specific frequencies —like ho...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Healthcare Delivery Healthcare Innovations Medical Research Source Type: blogs
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Park Yoon Chae Choi Kim Cho Due to the rare occurrence of young-onset bladder cancer (YBC), its genomic characteristics remain largely unknown. Twenty-nine biopsy-proven YBC cases were collected using a nation-wide search for bladder cancer diagnosed at 20 years or younger. Whole exome sequencing and RNA sequencing were carried out in 21 and 11 cases, respectively, and compared with those of adult bladder cancer (ABC) cases obtained from public databases. Almost all YBCs were low grade, non-invasive papillary tumors. YBC had a low mutation burden and less complex copy number alterations. All cases ha...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Bladder cancer is the most common malignant tumor of the urinary system, and it has high incidence, high degree of malignancy, and easy recurrence after surgery. The etiology and pathogenesis of bladder cancer are not fully understood, but more and more studies have shown that its development may be regulated by some core molecules. To identify key molecules in bladder cancer, we constructed a three-layer network by merging lncRNA-miRNA regulatory network, miRNA-mRNA regulatory network, and lncRNA-mRNA coexpression network, and further analyzed the topology attributes of the network including the degree, betweenness centra...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Condition:   Urinary Bladder Neoplasms Interventions:   Drug: Pembrolizumab;   Radiation: Conventional Radiotherapy (Bladder only);   Radiation: Conventional Radiotherapy (Bladder and pelvic nodes);   Radiation: Hypofractionated Radiotherapy (Bladder only);   Drug: Cisplatin;   Drug: Fluorouracil (5-FU);   Drug: Mitomycin C (MMC);   Dru g: Gemcitabine;   Drug: Placebo to Pembrolizumab Sponsor:   Merck Sharp & Dohme Corp. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(Vanderbilt University Medical Center) A five-year follow-up study of more than 2,000 US men who received prostate cancer treatment is creating a road map for future patients regarding long-term bowel, bladder and sexual function in order to clarify expectations and enable men to make informed choices about care.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Recent NICE guidance says there is limited evidence for the efficacy of transurethral laser ablation for recurrent non ‐muscle invasive bladder cancer and that ‘special arrangements’ need to be in place if it is to be offered to patients. Here the authors consider the advantages and drawbacks of the treatment.
Source: Trends in Urology and Men's Health - Category: Urology & Nephrology Authors: Tags: NICE guidance Source Type: research
ConclusionsClosure of VVF is a significant challenge, with an initial success rate of 20% and an overall success rate of only 25%. Seventy percent required primary or secondary urinary diversion. Vaginal surgery was utilised in the majority to try to avoid a hostile pelvis, but the surgical approach should be tailored to individual circumstances.
Source: International Urogynecology Journal - Category: OBGYN Source Type: research
Authors: Mehta S, Farnia B, de la Zerda A, Rahimi R, Wolfson A, Portelance L Abstract Purpose: Smit sleeves are used to facilitate insertion of the intrauterine tandem during brachytherapy for cervical cancer. When a tandem and ovoids system is used the base of the Smit sleeve displaces the ovoids distally. The dosimetric impact of this displacement is not known. Herein we performed a dosimetric analysis to quantify this impact on the integral dose and dose delivered to the organs at risk (OARs). Material and methods: Eleven high-dose-rate brachytherapy plans in which a Smit sleeve was used with a tandem and ov...
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
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