Long noncoding RNA SNHG14 accelerates cell proliferation, migration, invasion and suppresses apoptosis in colorectal cancer cells by targeting miR-944/KRAS axis through PI3K/AKT pathway.

CONCLUSIONS: SNHG14 contributed to cell proliferation, migration and invasion, while suppressed apoptosis in CRC cells by targeting miR-944/KRAS axis through PI3K/AKT pathway, representing novel biomarkers for CRC therapy. PMID: 31799655 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

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CONCLUSIONS: In women, the relation between BMI and MSI-high CRC seems to be stronger than that between BMI and microsatellite-stable CRC. However, a validation in an independent cohort is needed. This observational study was registered at the German Clinical Trials Register (http://www.drks.de; study ID: DRKS00011793), an approved primary register in the WHO network. PMID: 31897467 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Am J Clin Nutr Source Type: research
This article summarizes the associations between miR-429 and malignant tumors as well as potential action mechanisms. miR-429 has a potential to be used in the future as a biomarker for the diagnosis, treatment and prognosis of certain cancers. PMID: 31884798 [PubMed - as supplied by publisher]
Source: Neoplasma - Category: Cancer & Oncology Authors: Tags: Neoplasma Source Type: research
Conclusions: An algorithm comprising one inpatient or two outpatient ICD-9-CM diagnosis codes for endometrial adenocarcinoma had a high PPV. The results indicate that claims databases can be used to reliably identify cases of endometrial adenocarcinoma in studies seeking a high PPV. PMID: 31781220 [PubMed]
Source: Journal of Cancer Epidemiology - Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research
Authors: Kifle E, Hussein M, Alemu J, Tigeneh W Abstract Background: Anemia is a common finding in cancer, which is caused by many factors. It is a major cause of morbidity in cancer patients, worsens disease status and impairs treatment outcome; however, little is known about the prevalence of anemia and associated factors among cancer patients during diagnosis in developing countries like Ethiopia. In response to this, we have conducted research with the aim of assessing the prevalence of anemia and associated factors among newly diagnosed patients with solid malignancy at Tikur Anbessa Specialized Hospital (TASH...
Source: Advances in Hematology - Category: Hematology Tags: Adv Hematol Source Type: research
Conclusions: Buparlisib was well tolerated, however efficacy was limited despite selection of PI3K pathway aberrations. Future studies may provide insight into buparlisib efficacy by refining the molecular selection of different tumor types. PMID: 31741715 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Publication date: Available online 11 November 2019Source: Pathology - Research and PracticeAuthor(s): Heejin Bang, Soomin Ahn, Eun Ji Kim, Seung Tae Kim, Ha Young Park, Jeeyun Lee, Kyoung-Mee KimABSTRACTRapamycin-insensitive companion of mTOR (RICTOR) is a key component of mammalian target of rapamycin (mTOR) complex 2 (mTORC2), and promotes cellular proliferation and survival through the activation of downstream AGC kinase family members. The amplification of RICTOR has been proposed as a therapeutically relevant genomic alteration. However, other than next-generation sequencing, precise diagnostic methods to detect RICT...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Conditions:   Colorectal Cancer;   Colorectal Neoplasms;   Colorectal Carcinoma;   Colorectal Adenocarcinoma;   Colorectal Cancer Metastatic;   Colorectal Sarcoma Intervention:   Other: No intervention Sponsor:   ProgenaBiome Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Colorectal Cancer;   Colorectal Neoplasms;   Colorectal Carcinoma;   Colorectal Adenocarcinoma;   Colorectal Cancer Metastatic;   Colorectal Sarcoma Intervention:   Other: No intervention Sponsor:   ProgenaBiome Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Colorectal Cancer;   Colorectal Neoplasms;   Colorectal Carcinoma;   Colorectal Adenocarcinoma;   Colorectal Cancer Metastatic;   Colorectal Sarcoma Intervention:   Other: No intervention Sponsor:   ProgenaBiome Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Colorectal Cancer;   Colorectal Neoplasms;   Colorectal Carcinoma;   Colorectal Adenocarcinoma;   Colorectal Cancer Metastatic;   Colorectal Sarcoma Intervention:   Other: No intervention Sponsor:   ProgenaBiome Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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