CircHIPK3 aggravates myocardial ischemia-reperfusion injury by binding to miRNA-124-3p.

CONCLUSIONS: CircHIPK3 inhibits proliferative ability and induces apoptosis of cardiomyocytes after myocardial I/R injury by binding to miRNA-124-3p, which may serve as a potential therapeutic target for I/R. PMID: 31799682 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Related Links:

Increased rates of locoregional recurrence are observed in patients with basal-like breast cancer (BC) despite the use of radiation therapy (RT); therefore, approaches that result in radiosensitization of basal-like BC are critically needed. Using patients’ tumor gene expression data from 4 independent data sets, we correlated gene expression with recurrence to find genes significantly correlated with early recurrence after RT. The highest-ranked gene, TTK, was most highly expressed in basal-like BC across multiple data sets. Inhibition of TTK by both genetic and pharmacologic methods enhanced radiosensitivity in mul...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
With a focus on renal function, the goal of this multicentre study was to assess peri-operative complications and late mortality of open surgical repair (OSR) of juxtarenal abdominal aortic aneurysms (JRAAA).
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
In the November 2019 issue of the Journal of Vascular Surgery, the article by Dua et  al (Dua A, Rothenberg KA, Wohlaer M, Rossi PJ, Lewis BD, Brown KR, Seabrook GR, Lee CJ; Unplanned 30-day readmissions after endovascular aneurysm repair: An analysis using the Nationwide Readmissions Database. J Vasc Surg 2019;70:1603-11) should list Dr Dua's affiliation as Division of Vascular S urgery, Department of Surgery, Massachusetts General Hospital, Boston, Mass.
Source: Journal of Vascular Surgery - Category: Surgery Tags: Correction Source Type: research
Our study has demonstrated through analysis of the National Surgical Quality Improvement Program that inferior mesenteric artery (IMA) replantation does not sufficiently decrease the rates of ischemic colitis after an open abdominal aortic aneurysm (AAA) repair that is comparable to the cohort of patients who undergo IMA ligation.1 Lazaris and colleagues have expressed in their letter to the Editor that comparison of these two cohorts (open AAA repair with IMA replantation vs open AAA repair with IMA ligation) is not valid because of inherent underlying differences.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
Lee et  al1 report that inferior mesenteric artery (IMA) replantation does not decrease the risk of ischemic colitis after open infrarenal abdominal aortic aneurysm (AAA) repair. On the contrary, when there are intraoperative findings supporting IMA replantation, despite this additional procedure, the ris k of colonic ischemia is higher than after AAA repair without IMA replantation.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
Multiple renal arteries are a common renal vascular variant. A study with 800 kidneys from cadaver donors demonstrated 1% prevalence of quadruple renal arteries.1 During thoracoabdominal aortic aneurysm (TAAA) repair, this anomaly implies longer time of renal ischemia and well-defined reperfusion strategy.2 Acute kidney injury during TAAA repair is a common complication with 6% to 7% incidence.3,4 It can be prevented by histidine-tryptophan-ketoglutarate solution (Custodiol; Dr Franz-K öhler Chemie GmbH, Bensheim, Germany) renal perfusion.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Vascular images Source Type: research
Suprarenal abdominal aortic coarctation (SAAC) is a congenital midaortic syndrome that develops owing to a developmental anomaly in the fusion of the embryonic dorsal aortae. This condition is associated with severe hypertension, which is usually the indication for intervention. Open surgery is the primary treatment and it typically involves thoracoaortic bypass (TAB), and less commonly patch aortoplasty (PA). Bypass to the visceral vessels has also been performed in conjunction with TAB or PA. The majority undergoing intervention for SAAC are children and adolescents; therefore, the benefits of surgical intervention must ...
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Invited commentary Source Type: research
Medical technology is revolutionizing healthcare for patients worldwide and is now more than ever becoming crucial in the prevention, diagnosis, treatment, and management of numerous diseases. We are increasingly seeing the ability of medical technology to personalize treatments and target patients’ individual needs. However, to ensure we are enabling access to these treatments, regulatory agencies need to consider new approaches to the approval process. Historically, product approvals have focused on the standardization of a drug or a therapy to treat a large population of people with the same disease, s...
Source: MDDI - Category: Medical Devices Authors: Tags: Regulatory and Compliance Source Type: news
Conclusions: We provided evidence that ARID2 knockout could contribute to disruption of NER process through inhibiting the recruitment of XPG, resulting in susceptibility to carcinogens and potential hypermutation. These findings have far-reaching implications for therapeutic targets in cancers harboring ARID2 mutations.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Publication date: June 2020Source: Materials Today Communications, Volume 23Author(s): Zhaojie Feng, Mingchao Wang, Ruoyun Lu, Wence Xu, Ting Zhang, Tong Wei, Jingfang Zhang, Yunlong LiaoAbstractThe effect of whisker growing catalyzed by different amounts of AlF3 on the various properties of an epoxy/silicone resin-based high-temperature-resistant adhesive was comprehensively investigated. Although the addition of AlF3 promoted the oxidation reactions, accelerated the premature formation of mullite whiskers, increased the production of SiC ceramic, and reduced the thermal expansion of bonding layer, the excessive use of Al...
Source: Materials Today Communications - Category: Materials Science Source Type: research
More News: Cardiology | Drugs & Pharmacology | Gastroschisis Repair | Genetics | Heart