The Role of Cardiovascular and Metabolic Comorbidities in the Link between Atrial Fibrillation and Cognitive Impairment: An Appraisal of Current Scientific Evidence.
The Role of Cardiovascular and Metabolic Comorbidities in the Link between Atrial Fibrillation and Cognitive Impairment: An Appraisal of Current Scientific Evidence. Medicina (Kaunas). 2019 Nov 30;55(12): Authors: AlTurki A, Maj JB, Marafi M, Donato F, Vescovo G, Russo V, Proietti R Abstract Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice with implications on long-term outcomes. Metabolic disorders including diabetes mellitus and obesity are independent predictors of atrial fibrillation and present therapeutic targets to reduce both the incidence and duration burden of atrial fibrillation. The presence of pericardial fat in direct contact with cardiac structures, as well the subsequent release of proinflammatory cytokines, may play an important role in this connection. Atrial fibrillation is an independent predictor of cognitive impairment and dementia. While clinical stroke is a major contributor, other factors such as cerebral hypoperfusion and microbleeds play important roles. New evidence suggests that atrial fibrillation and cognitive impairment may be downstream events of atrial cardiomyopathy, which may be caused by several factors including metabolic syndrome, obesity, and obstructive sleep apnea. The mechanisms linking these comorbidities to cognitive impairment are not yet fully elucidated. A clearer understanding of the association of AF with dementia and cognitive impairment is imperative. Future studie...
ConclusionSubstantial agreement exists among experts regarding many strong recommendations for the improvement of practice concerning the use of muscle relaxants and reversal agents during anaesthesia. In particular, the French Society of Anaesthesia and Intensive Care (SFAR) recommends the use of a device to monitor neuromuscular blockade throughout anaesthesia.
Publication date: Available online 17 January 2020Source: Neuroscience ResearchAuthor(s): Zhaofa Wu, Yulong LiAbstractPurinergic transmitters such as adenosine, ADP, ATP, UTP, and UDP-glucose play important roles in a wide range of physiological processes, including the sleep-wake cycle, learning and memory, cardiovascular function, and the immune response. Moreover, impaired purinergic signaling has been implicated in various pathological conditions such as pain, migraine, epilepsy, and drug addiction. Examining the function of purinergic transmission in both health and disease requires direct, sensitive, non-invasive too...
Publication date: Available online 16 January 2020Source: NeuroscienceAuthor(s): Cao yuze, Zhang huixue, Lu xiaoyu, Wang Jianjian, Zhang xiaoming, Sun shengnan, Bao zhonglei, Tian wenqi, Ning shangwei, Wang lihua, Cui liyingAbstractThe nucleotide oligomerization domain (NOD)-like receptor (NLR) pyrin domain-containing protein 1 (NLRP1) inflammasome has been shown to contribute to brain injury after ischemic stroke. Our previous study showed that microRNA-9a-5p (miR-9a-5p) ameliorates ischemic injury by regulating neuronal autophagy in rats subjected to middle cerebral artery occlusion (MCAO) surgery. The aims of this study...
Conclusion: Administration of CoQ10 for 3 months in T1DM pediatric patients was well tolerated but had no favorable effect on ED or metabolic parameters. PMID: 31942840 [PubMed - as supplied by publisher]
Conclusions: PEG-HCC can improve some parameters of disease in these models and this may be due to a resulting increase in peripheral insulin sensitivity. However, additional studies are needed to elucidate how PEG-HCCs are producing these effects. PMID: 31937152 [PubMed - as supplied by publisher]
In conclusion, polyphenol compounds and their principal metabolites may contribute to counteracting human obesity via promoting WAT browning.
Most people know about the damaging effects that binge drinking can bring to someone’s life. Loss of enjoyment of life, losing family relationships, financial and career struggles, homelessness, and legal consequences are just the tip of the iceberg. However, it can be more difficult to realize the long-term effect of binge drinking on the body, because you cannot always see it. Frequent binge drinking poses many dangerous health risks, and many of them can lead to death. Facts on Long-Term Effect of Binge Drinking on the Body For men, binge drinking is defined as consuming five or more drinks within about two hour...
CONCLUSION: It is very important for public health that the current EU standards for rkedly lowered so that health risks can be further reduced, in accordance with the recommendations of the WHO. PMID: 31941576 [PubMed - in process]
Authors: Yoo R, Yeom J, Kim GH, Park HK, Kang Y, Hwang J, Choi SH, Na HR, Cho SJ, Yu KH, Kim DH, Lee JH, Jeong JH Abstract This corrects the article on p. 235 in vol. 15, PMID: 30938110. PMID: 31942782 [PubMed - in process]
Authors: Lai SW PMID: 31942773 [PubMed]
More News: Arrhythmia | Atrial Fibrillation | Cardiology | Cardiomyopathy | Cardiovascular | Dementia | Diabetes | Diabetes Mellitus | Eating Disorders & Weight Management | Endocrinology | Heart | Metabolic Syndrome | Obesity | Obstructive Sleep Apnea | Sleep Apnea | Sleep Disorders | Sleep Medicine | Stroke | Study | Universities & Medical Training