First report of Sarcocystis pilosa sporocysts in feces from red fox, Vulpes vulpes schrencki, in Hokkaido, Japan

Publication date: Available online 5 December 2019Source: International Journal for Parasitology: Parasites and WildlifeAuthor(s): Takao Irie, Kohji Uraguchi, Takuya Ito, Akiko Yamazaki, Shinji Takai, Kinpei YagiAbstractSarcocysts of various Sarcocystis spp. are highly prevalent in wild sika deer, Cervus nippon yesoensis, in Hokkaido, Japan, and four species have been identified based on morphological and molecular characteristics: S. ovalis, S. pilosa, S. tarandi-like, and S. truncata-like. The definitive hosts of S. ovalis are corvids, but the hosts of the other species have not yet been identified. Aiming to determine the definitive hosts of these species, we collected 65 red fox (Vulpes vulpes schrencki) fecal samples in eastern Hokkaido and examined them for fecal sporocysts using a modified sucrose flotation method. One fecal sample contained typical Sarcocystis sporocysts, which were identified as S. pilosa based on 18S ribosomal RNA and cytochrome c oxidase subunit I gene sequences. This is the first identification of S. pilosa sporocysts in the wild. These findings indicate that red foxes serve as a definitive host of S. pilosa, and that red foxes constitute a source of S. pilosa infection for deer in Hokkaido.Graphical abstract
Source: International Journal for Parasitology: Parasites and Wildlife - Category: Parasitology Source Type: research

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Date: Tuesday, 01 28, 2020; Speaker: Ricardo T. Gazzinelli, Professor, University of Massachusetts Medical School; 12735 Twinbrook Pkwy; 2nd Floor Conference Room
Source: NIH Calendar of Events - Category: American Health Source Type: events
Publication date: Available online 21 January 2020Source: Veterinary ParasitologyAuthor(s): Nabil Amor, Sarra Farjallah, Paolo Merella, Abdulaziz N Alagaili, Osama B. MohammedAbstractFasciolosis is a foodborne trematodosis characterised by a worldwide distribution. Various approaches have been developed for the study of the causative agents of this parasitic infection: Fasciola hepatica, Fasciola gigantica and the aspermic intermediated forms (hybrid and introgressed). In the present study, novel and common molecular markers (pepck and pold, ITS, CO1, ND1 and CO1-trnT-rrnL) were used to characterise Fasciola flukes from th...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Publication date: Available online 20 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Oscar Campetella, Carlos A. Buscaglia, Juan Mucci, María Susana LeguizamónAbstractMany important pathogen-host interactions rely on highly specific carbohydrate binding events. In the case of the protozoan Trypanosoma cruzi, the causative agent of Chagas disease, glycointeractions involving sialic acid (SA) residues are pivotal for parasite infectivity, escape from immune surveillance and pathogenesis. Though unable to synthesize SA de novo, T. cruzi displays a unique trans-Sial...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Source: Expert Opinion on Drug Discovery - Category: Drugs & Pharmacology Authors: Source Type: research
Conclusion: This paper features an autonomous, portable, 1-min analysis time, and low-cost per test device, without the need for samples, centrifugation, allowing the use of whole blood. Significance: The presented device is a step ahead for meeting the growing clinical demands for reliable, rapid, portable, and quantitative malaria diagnosis.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
This week's very cool case was donated by Dr. Mike Feely. We haven't had anything like this one before on the blog!The specimen below was submitted by a young woman who found this " worm " by her arm, right below her mouth, upon waking from a nap. She reported having abdominal pain with associated diarrhea for several weeks prior to presentation, but was otherwise healthy. After being in formalin:Histologic sections (H&E):Identification? Any additional information that you would like?
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
In this study, recombinant canine cytokines (rcaIL-12, rcaIL-2, rcaIL-15 and rcaIL-7) and soluble receptor IL-10R1 (rcasIL-10R1), with antagonistic activity, were evaluated for the first time in combination (rcaIL-12/rcaIL-2, rcaIL-12/rcaIL-15, rcaIL-12/rcasIL-10R1, rcaIL-15/rcaIL-7) or alone (rcasIL-10R1) to evaluate their immunomodulatory capacity in peripheral blood mononuclear cells (PBMC) from dogs with leishmaniasis. All the combinations of recombinant proteins tested were shown to improve lymphoproliferative response. Further, the combinations rcaIL-12/rcaIL-2 and rcaIL-12/rcaIL-15 promoted a decrease in programmed ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Conclusions/SignificanceNo statistically significant differences between the accuracy in smears, aspirate, skin biopsies or swabs samples were observed. Therefore, a simple smear sample run by PCR, instead more invasive samples, may be enough to obtain a positive diagnosis of CL. The results for PCR in all samples type confirm previous reports that consider PCR as the most accurate method for the diagnosis of CL.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
by Mariana Gatto, Patr ícia Aparecida Borim, Ivan Rodrigo Wolf, Taís Fukuta da Cruz, Gustavo Augusto Ferreira Mota, Aline Márcia Marques Braz, Bárbara Casella Amorim, Guilherme Targino Valente, Marjorie de Assis Golim, James Venturini, João Pessoa Araújo Junior, Alessandra Pontillo, Alexandrina Sartori Leishmaniasis is caused by intracellular parasites transmitted to vertebrates by sandfly bites. Clinical manifestations include cutaneous, mucosal or visceral involvement depending upon the host immune response and the parasite species. To assure their survival inside macrophages, t...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Conclusions/SignificanceLoratadine, cyproheptadine and clofazimine inhibit TcAAAP069 proline transporter and also present trypanocidal effect against allT.cruzi life stages in strains from three different DTUs. These CV structural analogues could be a starting point to design therapeutic alternatives to treat Chagas disease by finding new indications for old drugs. This approach, called drug repurposing is a recommended strategy by the World Health Organization to treat neglected diseases, like Chagas disease, and combination therapy may improve the possibility of success of repositioned drugs.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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