Identification and fine-mapping of a genetic locus underlying soybean tolerance to SMV infections

Publication date: Available online 5 December 2019Source: Plant ScienceAuthor(s): Jing Lin, Zejun Lan, Wenhuan Hou, Chunyan Yang, Dagang Wang, Mengchen Zhang, Haijian ZhiAbstractSoybean mosaic virus (SMV) is a major pathogen causing yield loss. Developing soybean plants tolerant or resistant to SMV is important for mitigating the adverse effects of the viral infection. However, most studies have focused on the resistance to normal SMV strains. Thus, investigations of the resistance or tolerance to the novel recombinant SMV strain have been limited. To address the threat of the recombinant SMV, two soybean parent genotypes with contrasting reactions to the recombinant SMV and 211 F9:11 recombinant inbred lines were evaluated under artificial inoculation conditions. The JD12 plants are resistant to the recombinant SMV, whereas HT is highly tolerant, but still susceptible. Genetic analyses suggested that the resistance of JD12 is controlled by a single dominant gene and the tolerance is a quantitative trait. The QTL mapping results revealed one QTL (qTsmv-13) for resistance and two QTLs (qTsmv-2 and qTsmv-3) for tolerance. A comparison between known resistance genes and the QTLs identified in this study suggested that qTsmv-13 and qTsmv-2 may correspond to Rsv1 and Rsv4, respectively, whereas qTsmv-3 represents a newly identified QTL for SMV tolerance. We further delimited qTsmv-3 to an interval of approximately 86 kb with a map-based cloning strategy. Only two of five ca...
Source: Plant Science - Category: Biology Source Type: research

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Publication date: Available online 22 January 2020Source: PeptidesAuthor(s): Anshul Panjeta, Simran PreetAbstractThe escalating predicament of multidrug resistant cancer cells and associated side effects of conventional chemotherapy necessitates the exploration of alternative anticancer therapies. The present study evaluated anticancer therapeutic potential of human defensin 5 (HD-5) against colon cancer. The in vivo anticancer efficacy of HD-5 against 1,2-dimethylhydrazine (DMH) induced colon cancer was elucidated in terms of tumor biostatistics, number of aberrant crypt foci (ACF), in situ apoptosis assay,changes in morp...
Source: Peptides - Category: Biochemistry Source Type: research
Publication date: Available online 20 December 2019Source: Journal of Hospital InfectionAuthor(s): B. Pilmis, T. Billard-Pomares, M. Martin, C. Clarempuy, C. Lemezo, C. Saint-Marc, N. Bourlon, D. Seytre, E. Carbonnelle, J-R. ZaharSUMMARYBackgroundLittle is known about patient risk factors associated with environmental contamination.AimTo evaluate the rate of environmental contamination and to investigate individual risk factors.MethodsA prospective cohort study was conducted. Each day, five rooms occupied by patients were selected. Five critical surfaces were systematically swabbed twice a day before and after cleaning. Cl...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
Chem. Commun., 2020, Advance Article DOI: 10.1039/C9CC06967D, CommunicationMohini Mohan Konai, Iqbal Pakrudheen, Swagatam Barman, Natalia Sharma, Khatija Tabbasum, Prashant Garg, Jayanta Haldar Cyclam-based antibacterial molecules (CAMs) that display potent activity against both the planktonic and stationary phase of multidrug-resistant Gram-negative bacteria were rationally designed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Antimicrobial resistant bacteria are emerging biological contaminants of the environment. In aquatic ecosystems, they originate mainly from hospitals, livestock manure and private households sewage water, whic...
Source: Acta Veterinaria Scandinavica - Category: Veterinary Research Authors: Tags: Research Source Type: research
ConclusionTo our knowledge, this is the first study that reports the widespread expansion of multidrug resistance amongUreaplasma serovars, a finding of importance in terms of both surveillance and antimicrobial usage.
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
ConclusionThis is the first report showing the high prevalence of carbapenemases in ESBL-positive isolates in this area. Regular surveillance for such resistance mechanisms will be useful for health personnel to treat infections by these multidrug-resistant pathogens.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
In this study, 43 Salmonella phages were isolated from environmental resources and among them, phage D1-2 was selected since it exhibited the most potent lytic ability and the broadest host spectrum against tested Salmonella strains. Further study demonstrated that D1-2 shows high pH and thermal tolerances and a short latent period, together with a low frequency of emergence of phage resistance. D1-2 effectively inhibited the growth of two MDR Salmonella strains in liquid egg white and egg yolk at both 4 °C and 25 °C. Morphology and phylogeny indicated that D1-2 belongs to the Myoviridae family. Genome analysis of ...
Source: Food Research International - Category: Food Science Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
AbstractOmadacycline is a novel aminomethylcycline antibiotic developed as a once-daily, intravenous and oral treatment for acute bacterial skin and skin structure infection (ABSSSI) and community-acquired bacterial pneumonia (CABP). Omadacycline, a derivative of minocycline, has a chemical structure similar to tigecycline with an alkylaminomethyl group replacing the glycylamido group at the C-9 position of the D-ring of the tetracycline core. Similar to other tetracyclines, omadacycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline possesses broad-spectrum antibacterial activit...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
AbstractIbalizumab (Trogarzo®; ibalizumab-uiyk) is the first monoclonal antibody to be approved for the treatment of HIV-1 infection. As a CD4-directed post-attachment inhibitor, ibalizumab blocks HIV-1 entry into CD4 cells while preserving normal immune function. Ibalizumab, in combination with other antiretroviral(s), is indicated in the USA for the treatment of heavily treatment-experienced adults with multidrug-resistant HIV-1 infection failing their current antiretroviral regimen, and in the EU for the treatment of adults infected with multidrug-resistant HIV-1 infection for whom it is otherwise not possible to co...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
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