Reviews may overestimate the effectiveness of medicines for back pain: systematic review and meta-analysis

Systematic-reviews of analgesics for low back pain generally include published data only. Obtaining data from unpublished trials is potentially important because they may impact effect sizes in meta-analyses. We determined whether including unpublished data from trial registries changes the effect sizes in meta-analyses of analgesics for low back pain.
Source: Journal of Clinical Epidemiology - Category: Epidemiology Authors: Tags: Review Source Type: research

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AbstractPurpose of the ReviewSacral insufficiency fractures (SIF) are a common and often underdiagnosed source of low back pain. In patients with SIF, there is both a compromised sacroiliac joint and weakened sacrum, resulting in decreased resistance to torsional stress, leading to fracture. While conservative medical management is a safe option, minimally invasive intervention may provide improved short and long-term relief of low back pain in patients presenting with SIF. This comprehensive review is undertaken to provide an update to the current understanding of SIF with description of risk factors, clinical presentatio...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
ConclusionsThese data suggest OXT ‐related modulation of regional activity and neural network strength in patients with cLBP and healthy controls. In patients, distinct regions of the pain matrix may be responsive to modulation by OXT.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Abstract Pain is an unpleasant sensory and emotional experience in many diseases and is often caused by intense or damaging stimuli. Pain negatively affects the quality of life and increases high health expenditures. Drugs with analgesic properties are commonly used to relieve pain, but these Western medications could be overwhelmed by side effects including tolerance and addiction. Herbal medicines may provide alternative measures for pain management. In this review paper, after introduction of Chinese medicine theory and treatment modality, emphasis is placed on the application of Chinese herbs and herbal formul...
Source: The American Journal of Chinese Medicine - Category: Complementary Medicine Authors: Tags: Am J Chin Med Source Type: research
Publication date: Available online 15 February 2020Source: NeuroImageAuthor(s): Minhae Kim, Ishtiaq Mawla, Daniel S. Albrecht, Roee Admon, Angel Torrado-Carvajal, Courtney Bergan, Ekaterina Protsenko, Poornima Kumar, Robert R. Edwards, Atreyi Saha, Vitaly Napadow, Diego A. Pizzagalli, Marco L. LoggiaAbstractBackgroundChronic pain and mood disorders share common neuroanatomical substrates involving disruption of the reward system. Although increase in negative affect (NA) and decrease in positive affect (PA) are well-known factors complicating the clinical presentation of chronic pain patients, our understanding of the mech...
Source: NeuroImage - Category: Neuroscience Source Type: research
Conclusions: Our results confirmed the perpendicularity of the interlaminar line with the pedicle axis in the lumbar spine at all the levels. The interlaminar line is a useful guide for pedicle screw sagittal inclination. PMID: 32050312 [PubMed - as supplied by publisher]
Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
Condition:   Low Back Pain, Mechanical Interventions:   Other: Multidimensional physiotherapy;   Other: Usual physiotherapy Sponsor:   Iran University of Medical Sciences Not yet recruiting
Source: - Category: Research Source Type: clinical trials
AbstractObjectiveTo report in vivo measurements of lumbar facet joint subchondral bone mineral density used in the description of facet joint loading patterns and to interrogate if low back pain is associated with changes in subchondral bone mineral density.Materials and methodsIn vivo measurements of lumbar facet joint subchondral bone mineral density (L1/2 to L5/S1) in Hounsfield units were performed on 89 volunteers (56 controls and 33 with low back pain) by computed tomography osteoabsorptiometry at subchondral regions between 1.5  mm and 2.5 mm below the joint surface. The facet surface was divided into five...
Source: Skeletal Radiology - Category: Radiology Source Type: research
CONCLUSIONS: From current studies, it appears that CES occurs infrequently in asymptomatic community populations and in only 19% of those presenting with symptoms. Determining accurate incidence figures and designing a bespoke service for investigation of patients with suspected CES would require a consensus clinical and radiological definition of CES and international multisite studies of patient pathways of investigation and management. PMID: 32059184 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery.Spine - Category: Neurosurgery Authors: Tags: J Neurosurg Spine Source Type: research
ConclusionPVM decrease was significantly related to LBP and delayed union after osteoporotic vertebral fracture onset. ADL decline at the 3-month follow-up was a risk factor for PVM decrease. Therefore, restoring ADLs within 3  months after onset is important.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
ATLANTA—The potential of cannabis‐based medicines is a hot topic, particularly as pain management therapy for arthritis and other conditions. However, confusion abounds regarding its therapeutic potential, how it can be administered and even the correct terminology to use. David P. Finn, PhD, professor of pharma­cology and therapeutics, and founding co-director of the Centre for Pain... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: 2019 ACR/ARP Annual Meeting Conditions Spondyloarthritis Axial Spondyloarthritis chronic low-back pain HLA-B27 Source Type: research
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