Hemophagocytic syndrome and the influenza virus (H3N2)

Publication date: Available online 6 December 2019Source: Revista Clínica Española (English Edition)Author(s): M. Martín Asenjo, J.M. Martín Guerra, J.M. Prieto de Paula
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research

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This study suggests that chronic arsenite exposure could result in enhanced influenza infection in epithelial cells, and that this may be mediated through increased sialic acid binding. Finally, the decreased effectiveness of the anti‐influenza drug, oseltamivir, in arsenite‐exposed cells raises substantial public health concerns if this effect translates to arsenic‐exposed, influenza‐infected people.
Source: Journal of Applied Toxicology - Category: Toxicology Authors: Tags: RESEARCH ARTICLE Source Type: research
Flu season is always unpredictable. Different viral strains circulate each year, which makes forecasting the disease’s spread—and formulating the annual flu vaccine—an educated guessing game. Even so, the 2019-2020 flu season has been particularly unusual. Influenza B, the viral strain that usually circulates toward the end of flu season, instead emerged first this year, shifting usual transmission patterns. A vaccine mismatch and reduced immunity to influenza B may have contributed to the early and severe start of this flu season. What does that mean for the months ahead? TIME asked Lynnette Brammer, an ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Infectious Disease Source Type: news
(CNN) — This year’s flu vaccine is “not a very good match” for a common strain of the flu that’s especially tough on children, according to the nation’s top infectious disease doctor. “It’s not a very good match for B/Victoria,” said Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, referring to the strain. “It’s not an awful match, but it’s not a very good match.” Children are particularly susceptible to influenza B/Victoria. Fauci said even though the match for B/Victoria isn’t great, a flu shot can...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Syndicated CBSN Boston CNN Flu Vaccine Source Type: news
CONCLUSIONS: The immunogenicity of QIV for common ingredients was similar to that of TIV, but the former exhibited significantly higher immunogenicity for the unique lineage. QIV also had the same reliable safety as TIV. PMID: 31948819 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Abstract Avian influenza A viruses (AIVs) classify into 18 hemagglutinin (HA) and 11 neuraminidase (NA) subtypes. Even though H1N1 and H3N2 subtypes usually circulate among humans leading to infection, occasionally, H5, H6, H7, H9, and H10 that circulate in poultry also infect humans, and especially H5N1 and H7N9. Efficient virus replication is a critical factor that influences infection. Codon usage of a virus must coevolve with its host for efficient viral replication, therefore, we conduct a comprehensive analysis of codon usage bias in human-isolated AIVs to test their adaptation to host expression system. The...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
Abstract Canada's national influenza season started in week 47 between November 17 to 23, 2019. Of the 3,762 laboratory-confirmed influenza detections reported from August 25 to December 14, 2019, 61% were influenza A, and of those subtyped, 68% were A(H3N2). Influenza B detections are above average for this time of year. Indicators of influenza activity are within the expected range for this time of year. The majority of hospitalizations reported by provinces and territories have been associated with influenza A(H3N2) (76%), and the greatest proportion have been among adults 65 years and older (40%). Among sentin...
Source: Can Commun Dis Rep - Category: Infectious Diseases Authors: Tags: Can Commun Dis Rep Source Type: research
Conclusions: Our results show that IFN- α subtypes differ in their ability to repress H3N2 replication in human lung tissue and emphasize that IFN-α subtypes α16, α5 and α4 have high therapeutic potential and should be further investigated for the prevention and treatment of severe infections with seasonal H3N2.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Publication date: 24 December 2019Source: Cell Reports, Volume 29, Issue 13Author(s): Seth J. Zost, Juhye Lee, Megan E. Gumina, Kaela Parkhouse, Carole Henry, Nicholas C. Wu, Chang-Chun D. Lee, Ian A. Wilson, Patrick C. Wilson, Jesse D. Bloom, Scott E. HensleySummaryAntibodies targeting the receptor binding site (RBS) of the influenza virus hemagglutinin (HA) protein are usually not broadly reactive because their footprints are typically large and extend to nearby variable HA residues. Here, we identify several human H3N2 HA RBS-targeting monoclonal antibodies (mAbs) that are sensitive to substitutions in conventional anti...
Source: Cell Reports - Category: Cytology Source Type: research
Condition:   Influenza A H3N2 Intervention:   Device: Lumee Oxygen Platform Sponsors:   Imperial College London;   Duke University;   RTI International;   Defense Advanced Research Projects Agency Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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