' Spark of Hope' for Tau Inhibitor in Alzheimer's Disease'Spark of Hope' for Tau Inhibitor in Alzheimer's Disease

Low-dose hydromethylthionine may help prevent both cognitive decline and brain atrophy in early Alzheimer's disease, new exploratory research suggests.Medscape Medical News
Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Psychiatry News Source Type: news

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Authors: Orso B, Mattei C, Arnaldi D, Massa F, Serafini G, Plantone D, Doglione E, Grafman J, Nobili F, Pardini M Abstract OBJECTIVE: As an analogy with mild cognitive impairment (MCI), the mild behavioral impairment (MBI) construct has been proposed as a diagnostic label for those presenting late-onset behavioral symptoms. To date, however, the clinical, cognitive, and structural imaging features associated with an increased risk of conversion from MBI to dementia are poorly understood. METHODS: We retrospectively analyzed the cognitive performance and structural brain MRI of 113 subjects, with a clinical foll...
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
Publication date: Available online 13 January 2020Source: Sensors and Actuators B: ChemicalAuthor(s): Yong Kyoung Yoo, Gangeun Kim, Dongsung Park, Jinsik Kim, YoungSoo Kim, Hye Yun Kim, Seung Hoon Yang, Jeong Hoon Lee, Kyo Seon HwangAbstractAmyloid-β (Aβ) is a peptide that is produced in the brain and carried across the blood brain barrier to the blood. It is an important biomarker for the blood-based diagnosis of early stage Alzheimer's disease (AD). However, the challenges of using blood Aβ are that there are several isoforms of the peptide and that the difference in concentration of the peptide in the blo...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Authors: Negi N, Das BK Abstract The discovery of an active lymphatic system in the meninges (dura mater) has opened up a wide range of possibilities for the role of CNS immunoglobulins in brain development in early fetal life or during infancy. The antibody-dependent and -independent functions of B cells in the immunopathogenesis of multiple sclerosis are not new to immunologists, yet their role in other neurodegenerative disorders such as Alzheimer's and Parkinson's disease is incompletely understood. Deep cervical lymph nodes have emerged as a candidate site for autosensitization against CNS antigens and have be...
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
Date: Tuesday, 02 25, 2020; Speaker: Lorna Role, PhD, NINDS; Dimitrios Kapogiannis, MD, NIA; Building: Building 50; 1227/1233; CME Credit; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
Clearing amyloid-β from the brain has failed to reverse Alzheimer's disease in patients, and this unfortunate outcome is slowly - all too slowly - producing a change in direction in the mainstream of Alzheimer's research. One possible conclusion is that amyloid-β is simply the wrong target, and this has led to a great deal of alternative theorizing in recent years. Even so, the consensus remains that amyloid-β does play a significant role in the condition, albeit not enough of a role in the later stages of Alzheimer's to allow anti-amyloid therapies to work. The jury remains out on whether early reduction in...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
This study applied a new two-level strategy to investigate and ensure the accuracy and consistency of the results. This strategy can be used to determine the association between the gut microbiome and serum metabolome in APP/PS1 transgenic mice and C57BL/6J male mice. The "4C0d-2 spp.-Cholesterol," "CW040 spp.-L-valine," "CW040 spp.-L-acetylcarnitine," "RF39 spp.-L-valine," "TM7-3 spp.-L-valine," and "TM7-3 spp.-L-acetylcarnitine" associations among specific "microbiota-metabolite" pairs were further identified based on univariate and multivariate correl...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Condition:   Alzheimer Disease Intervention:   Drug: Hope Biosciences Autologous Adipose-Derived Mesenchymal Stem Cells Sponsor:   Hope Biosciences Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion Pooled analysis suggest that patients with atrial fibrillation may be exposed to an increased risk of developing new onset of Alzheimer's disease. Given the relevant clinical implications, further studies are required to corroborate these findings.
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Research articles: Arrhythmias Source Type: research
We report a role of EFhd2 in METH‐induced locomotor activation and in the conditioned locomotor effects. No role, however, was observed in the establishment of METH‐ or cocaine‐induced conditioned place preference. These findings may suggest that EFhd2 modulates the activity of the dopaminergic system and the neurochemical effects of METH and cocaine, which translate into a modulation of the behavioural effects of these drugs at the l evel of the acute and conditioned locomotor activity.
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research
In this study, we developed a structural MR-based biomarker for in vivo detection of AD using a supervised machine learning approach. Based on an individual’s pattern of brain atrophy a continuous AD score is assigned which measures the similarity with brain atrophy patterns seen in clinical cases of AD.Methods: The underlying statistical model was trained with MR scans of patients and healthy controls from the Alzheimer’s Disease Neuroimaging Initiative (ADNI-1 screening). Validation was performed within ADNI-1 and in an independent patient sample from the Open Access Series of Imaging Studies (OASIS-1). In ad...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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