Empowering mucosal healing with an engineered probiotic

(Wyss Institute for Biologically Inspired Engineering at Harvard) Harvard Wyss Institute researchers developed a living material approach that uses a strain of genetically engineered E.coli Nissle bacteria as a locally acting probiotic. The engineered bacteria produce a network of nanofibers that directly binds to mucus to fill inflamed areas like a patch, shielding them from gut microbes and environmental factors. This probiotic-based therapeutic strategy protected mice against the effects of colitis induced by a chemical agent and promoted mucosal healing.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news