Empowering mucosal healing with an engineered probiotic

(Wyss Institute for Biologically Inspired Engineering at Harvard) Harvard Wyss Institute researchers developed a living material approach that uses a strain of genetically engineered E.coli Nissle bacteria as a locally acting probiotic. The engineered bacteria produce a network of nanofibers that directly binds to mucus to fill inflamed areas like a patch, shielding them from gut microbes and environmental factors. This probiotic-based therapeutic strategy protected mice against the effects of colitis induced by a chemical agent and promoted mucosal healing.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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ConclusionsThus, hMCs exhibit a highly individualized pattern of immune response possibly to meet tissue requirements and regulate bacteria coexistence vs defense.
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Publication date: Available online 30 March 2020Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Kristen Fernandez, Sara D’Souza, Jenny J. Ahn, Summer Singh, Erin Mae Bacasen, Daniel Mashiach, Daniel Mishail, Timothy Kao, Jasmine Thai, Spring Hwang, Lekha Yaramada, Jeffrey H. Miller
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - Category: Cytology Source Type: research
Publication date: Available online 30 March 2020Source: LWTAuthor(s): David R. Kasler, Taras Pyatkovskyy, Ahmed E. Yousef, Sudhir K. Sastry
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
The antimicrobial susceptibility testing of 284 Enterobacteriaceae isolates responsible for urinary tract infections to ampicillin, ceftazidime, ciprofloxacin, nitrofurantoin, trimethoprin-sulfamethaxole, and fosfomycin was performed by disk diffusion method. Additionally, in fosfomycin-resistant and intermediate susceptible isolates using disk diffusion method, the minimum inhibitory concentration (MIC) of fosfomycin was determined by agar dilution. The presence of fosA and fosA3 genes and ESBL genes was investigated in fosfomycin-resistant isolates and ESBL-producing isolates, respectively. Klebsiella pneumoniae [72.34% ...
Source: Reviews in Medical Microbiology - Category: Microbiology Tags: BACTERIOLOGY Source Type: research
Circulating androgens prime the kidney for fibrosis upon infectious injury (Escherichia coli pyelonephritis) by enhancing local TGF β1 production and myofibroblast activation. AbstractRenal scarring after pyelonephritis is linked to long ‐term health risks for hypertension and chronic kidney disease. Androgen exposure increases susceptibility to, and severity of, uropathogenicEscherichia coli (UPEC) pyelonephritis and resultant scarring in both male and female mice, while anti ‐androgen therapy is protective against severe urinary tract infection (UTI) in these models. This work employed androgenized female C57BL/...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Publication date: Available online 30 March 2020Source: Catalysis CommunicationsAuthor(s): W.P. Cathie Lee, Terence L. Perix, Kulandai Arockia Rajesh Packiam, Meei-Mei Gui, Chien Wei Ooi, Siang-Piao Chai
Source: Catalysis Communications - Category: Chemistry Source Type: research
[Actividad antimicrobiana de hongos endófitos de las plantas medicinales Mammea americana (Calophyllaceae) y Moringa oleifera (Moringaceae)]. Biomedica. 2020 Mar 01;40(1):55-71 Authors: Mosquera WG, Criado LY, Guerra BE Abstract Introducción. Las enfermedades infecciosas son una causa importante de muertes en el mundo. La resistencia antimicrobiana es un problema global, por lo que es conveniente la investigación de nuevas fuentes de agentes antimicrobianos de origen natural potencialmente efectivos. Objetivo. Evaluar la actividad antimicrobiana de hongos endófitos de Mammea...
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
Cortisol inhibits the Escherichia coli-induced endometrial inflammatory response through NF-κB and MAPK pathways in postpartum goats. Anim Reprod Sci. 2020 Apr;215:106333 Authors: Cui L, Zheng Y, Wang H, Dong J, Li J, Song Q, Qian C, Li J Abstract Glucocorticoids have been widely used as anti-inflammatory therapies. The mechanisms of cortisol action in goat does with endometritis, however, have not been reported. The aim of this study was to investigate the mechanism of cortisol in modulation of effects of E. coli-induced endometritis in the does. Does (n = 24) were assigned to four groups (...
Source: Animal Reproduction Science - Category: Zoology Authors: Tags: Anim Reprod Sci Source Type: research
AbstractThe family of AlkB homolog (ALKBH) proteins, the homologs ofEscherichia coli AlkB 2 ‐oxoglutarate (2OG), and Fe(II)‐dependent dioxygenase are involved in a number of important regulatory processes in eukaryotic cells including repair of alkylation lesions in DNA, RNA, and nucleoprotein complexes. There are nine human and thirteenArabidopsis thaliana ALKBH proteins described, which exhibit diversified functions. Among them, human ALKBH5 and FaT mass and Obesity ‐associated (FTO) protein and Arabidopsis ALKBH9B and ALKBH10B have been recognized as N6 methyladenine (N6meA) demethylases, the most abundant posttra...
Source: IUBMB Life - Category: Research Authors: Tags: SPECIAL ISSUE Source Type: research
Publication date: Available online 29 March 2020Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Sahar Nouri Gharajalar, Parviz Hassanzadeh, Nasrin Hosseinali Nejad
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
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