The ASPIRE Trial - Aiming for Safe Pregnancies by Reducing Malaria and Infections of the Reproductive Tract

Conditions:   Pregnancy Malaria;   Bacterial Vaginoses;   Trichomonas Vaginitis Interventions:   Drug: IPTp-sulphadoxine-pyrimethamine plus metronidazole;   Drug: IPTp-dihydroartemisinin-piperaquine plus metronidazole;   Drug: IPTp-sulphadoxine-pyrimethamine Sponsor:   London School of Hygiene and Tropical Medicine Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Date: Friday, 01 24, 2020; Speaker: Peter D. Crompton, M.D., M.P.H. , Chief, Malaria Infection Biology and Immunity Unit , Laboratory of Immunogenetics, NIAID ; Building 1; Wilson Hall ; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
In this study, we analyzed 677,423 human body temperature measurements from three different cohort populations spanning 157 years of measurement and 197 birth years. We found that men born in the early 19th century had temperatures 0.59°C higher than men today, with a monotonic decrease of -0.03°C per birth decade. Temperature has also decreased in women by -0.32°C since the 1890s with a similar rate of decline (-0.029°C per birth decade). Although one might posit that the differences among cohorts reflect systematic measurement bias due to the varied thermometers and methods used to obtain temperatures, we...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Malaria remains a global health problem and accurate surveillance of Plasmodium parasites that are responsible for this disease is required to guide the most effective distribution of control measures. Serologica...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Methodology Source Type: research
Malaria prevalence has significantly reduced since 2000, largely due to the scale-up of vector control interventions, mainly indoor residual spraying (IRS) and long-lasting insecticide-treated nets (LLINs). Gi...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Opinion Source Type: research
Anopheles maculipennis complex, the historic vector of malaria, causes serious medical problems worldwide and exhibits different behaviours. Studying the odorant-binding proteins (OBPs), which influence the chemo...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
The larval environment of holometabolous insects determines many adult life history traits including, but not limited to, rate and success of development and adult lifespan and fecundity. The ancient stress signaling hormone abscisic acid (ABA), released by plants inundated with water and by leaf and root fragments in water, is likely ubiquitous in the mosquito larval environment and is well known for its wide ranging effects on invertebrate biology. Accordingly, ABA is a relevant stimulus and signal for mosquito development. In our studies, the addition of ABA at biologically relevant levels to larval rearing containers a...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
[Government of Mauritius] 'An inter-sectoral collaboration is key to control and prevent the outbreak of vector-borne diseases such as malaria, dengue and chikungunya, in particular during the currently prevailing cyclonic and rainy season'.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
In endemic areas, pregnant women are highly susceptible to Plasmodium falciparum malaria characterized by the accumulation of parasitized red blood cells (pRBC) in the placenta. In subsequent pregnancies, women d...
Source: BMC Medicine - Category: Internal Medicine Authors: Tags: Research article Source Type: research
The sensitivity of rapid diagnostic tests (RDTs) for malaria is inadequate for detecting low-density, often asymptomatic infections, such as those that can occur when screening pregnant women for malaria. The ...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Publication date: Available online 14 January 2020Source: Parasitology InternationalAuthor(s): Takahiro Ishizaki, Nattawat Chaiyawong, Hassan Hakimi, Masahito Asada, Mayumi Tachibana, Tomoko Ishino, Kazuhide Yahata, Osamu KanekoAbstractMalaria parasites proliferate by repeated invasion of and multiplication within erythrocytes in the vertebrate host. Sexually committed intraerythrocytic parasites undergo sexual stage differentiation to become gametocytes. After ingestion by the mosquito, male and female gametocytes egress from erythrocytes and fertilize within the mosquito midgut. A complex signaling pathway likely respond...
Source: Parasitology International - Category: Parasitology Source Type: research
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