Daily briefing: Sounds of life revitalize reefs
Nature, Published online: 06 December 2019; doi:10.1038/d41586-019-03788-7Piped-in sounds of a healthy reef tempt young fish to re-colonize degraded areas. Plus: The San Andreas and Cascadia earthquake faults might be linked and how to build a better malaria vaccine.
(Walter Reed Army Institute of Research) WRAIR scientists demonstrated that a novel, second-generation malaria vaccine candidate based on the tobacco mosaic virus may offer protection against Plasmodium falciparum malaria. Malaria, infecting approximately 228 million individuals in 2018, remains a meaningful threat to public health, regional stability and deploying Service Members. This research shows that the TMV coat protein can also be highly effective as a vaccine scaffold to refocus the host immune system to the most vulnerable epitopes on circumsporozoite protein.
Patients with symptoms advised to call GP rather than attend practice Related items fromOnMedica Warn patients that natural malaria immunity fades Single-dose malaria drug eliminates parasite from liver Should we have compulsory measles vaccination at school entry? Parents still following folklore methods for cold prevention Double check patients with ‘penicillin’ allergy to avoid MRSA risk
Conclusions: This first detailed characterization of novel EXP1-specific T cell epitopes provides important information for future analysis with major histocompatibility complex-multimer technology as well as for immunomonitoring and vaccine design.
CONCLUSIONS: The general protection measures against malaria were met in a high percentage, whilst the use of chemoprophylaxis was very low. These epidemiological data allowed us to know the validity of the health education that is provided in the traveller's care consultation. It also allowed being aware of the possibilities of infection and import of malaria by personnel of the Spanish Armed Forces. The traveller's office will reinforce the importance of taking the adequate chemo-prophylaxis trough conferences and informative diptychs.. PMID: 31965778 [PubMed - as supplied by publisher]
In this study, we investigated combining two liver-stage antigens, P. falciparum LSA1 (PfLSA1) and PfLSAP2, and investigated the induction of protective efficacy by coadministration of single-antigen vectors or vaccination with dual-antigen vectors, using simian adenovirus and modified vaccinia virus Ankara vectors. The efficacy of these vaccines was assessed in mouse malaria challenge models using chimeric P. berghei parasites expressing the relevant P. falciparum antigens and challenging mice at the peak of the T cell response. Vaccination with a combination of the single-antigen vectors expressing PfLSA1 or PfLSAP2 was ...
ConclusionOur findings show that the protective efficacy shown by SLTRiP is localized in particular protein fragments. The peptides designed from such regions showed protective efficacy equivalent to whole protein. The sequence conservation analysis with humanPlasmodium species also showed that these peptides were conserved. In conclusion, these peptides or their equivalent from otherPlasmodium species could impart protection against malaria in their respective hosts too. Our studies provide a basis for the inclusion of these peptides in clinical vaccine constructs against malaria.
Netter : Hepatitis B remains one of the major global health problems more than 40 years after the identification of human hepatitis B virus (HBV) as the causative agent. A critical turning point in combating this virus was the development of a preventative vaccine composed of the HBV surface (envelope) protein (HBsAg) to reduce the risk of new infections. The isolation of HBsAg sub-viral particles (SVPs) from the blood of asymptomatic HBV carriers as antigens for the first-generation vaccines, followed by the development of recombinant HBsAg SVPs produced in yeast as the antigenic components of the second-generation va...
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...