Different mechanisms of the protection against influenza A infection mediated by broadly reactive HA2-specific antibodies.

Different mechanisms of the protection against influenza A infection mediated by broadly reactive HA2-specific antibodies. Acta Virol. 2019;63(4):347-365 Authors: Tomčíková K, Varečková E Abstract Influenza A viruses (IAVs) cause yearly repeating infections in humans. The current vaccination approach is based on the production of virus-neutralizing antibodies. Virus-neutralizing antibodies, however, are closely strain-specific due to the IAV variability. Therefore, antibodies produced during the previous influenza season do not provide sufficient protection against new infection, and, hence, annual revaccination is needed. The utilization of the influenza conserved stem domain of hemagglutinin (HA), the HA2 gp, led to a new vaccine design based on cross-reactive cellular and especially humoral immune responses represented by HA2-specific antibodies. The HA2-specific antibodies exhibit cross-reactivity with HA2 gp within one subtype or even among subtypes and play a role in protective immunity against influenza infection. There are several elimination mechanisms of viral replication mediated by HA2-specific antibodies. After recognition of the epitope, they prevent the conformational rearrangement of HA or the insertion of the fusion protein into the endosomal membrane and, consequently, the fusion pore formation. In this case, no release of viral genetic information into the target cell is enabled and virus cannot replicate. T...
Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research

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Date: Tuesday, 05 26, 2020; Speaker: Peter Palese, Ph.D. , Professor, Ichan School of Medicine at Mount Sinai; Building: Building 40; CR1201/1203
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A rapidly evolving health story broke in late December when a novel illness originating in Wuhan, China made the news. Reports of the number of infected people swiftly rose, and isolated cases of this new coronavirus — dubbed 2019-nCoV by scientists — have appeared in several countries due to international travel. At this writing, almost 1,300 confirmed cases and over 40 deaths have occurred in China, according to an article in the New York Times. Fortunately, public health officials in many countries, including the US, have put measures in place to help prevent further spread of the virus. These measures inclu...
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Contributors : John S Tregoning ; January Weiner 3rdSeries Type : Expression profiling by arrayOrganism : Mus musculusVaccination in pregnancy is an effective tool to protect both the mother and infant. Vaccines against tetanus, pertussis and influenza are recommended for use in pregnancy and new vaccines with specific indications for pregnancy are in the clinical trials pipeline. However our understanding of the immune response to vaccination in pregnancy is incomplete. We compared the effect of pregnancy on early (24 hours) transcriptional responses to vaccination. Pregnant mice and women were immunised with Boostrix-IPV...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
FRIDAY, Jan. 24, 2020 -- Many U.S. adults are misinformed about the influenza virus and the importance of flu vaccination, according to the results of a survey released by the American Academy of Family Physicians (AAFP). Wakefield Research...
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Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.9b00620
Source: Journal of Proteome Research - Category: Biochemistry Authors: Source Type: research
Publication date: Available online 23 January 2020Source: Heart &LungAuthor(s): Titilope Olanipekun, Valery S. Effoe, Olalekan Olanipekun, Efehi Igbinomwanhia, Onaopepo Kola-Kehinde, Claudia Fotzeu, Nicolas Bakinde, Rachael HarrisAbstractBackgroundEvidence suggests that annual influenza vaccination may prevent acute heart failure exacerbation episodes and improve survival.ObjectiveDetermine the influenza vaccination rate among African American patients with heart failure and identify predictors of uptake.MethodsAfrican American patients with heart failure were recruited at Grady Memorial Hospital, Atlanta GA between Oc...
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
Abstract Infants are at increased risk for pertussis-associated morbidity and mortality, and pregnant women and their infants are more likely than other patient populations to experience severe influenza-related illness (1,2). The Advisory Committee on Immunization Practices (ACIP) recommends that all women receive the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine during each pregnancy, preferably during the early part of gestational weeks 27-36 (3). ACIP also recommends that women who are or might be pregnant during the influenza season receive the inactivated influenza vaccine...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
BOSTON (CBS) – A teenager from Worcester County has died from the flu. State health officials say it is the first influenza-associated pediatric death of this flu season in the state. The child tested positive for Influenza B. The Department of Public Health is urging people who have not received a flu shot to get vaccinated. “This is a tragic reminder of how serious the flu can be for both children and adults,” said Public Health Commissioner Monica Bharel. “Every flu season is different, but January and February are typically the height of flu season. We want people to know that it’s not t...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated CBSN Boston Syndicated Local Flu Worcester news Source Type: news
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