Development and validation of loop-mediated isothermal amplification for the detection of the Zika virus.

In conclusion, this method provides a low-cost, high-performance, viable, and reliable alternative for the rapid diagnosis of Zika in primary health-care facilities. PMID: 31800936 [PubMed - in process]
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research

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Authors: Pereira AM, Araujo Júnior E, Werner H, Monteiro DLM Abstract Introduction Aim of the study was to evaluate the association between microcephaly and acute infection with Zika virus (ZIKV) in pregnant women in the state of Rio de Janeiro, Brazil. Infection was confirmed by laboratory testing. Materials and Methods A cross-sectional retrospective study of pregnant women with symptoms occurring between 2015 and 2016 suggestive of acute ZIKV infection was carried out, with confirmation of infection done by blood or urine RT-PCR. The relative proportions of categorical variables were calculated for two di...
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
Publication date: Available online 16 January 2020Source: Cell ReportsAuthor(s): Shaobo Wang, Qiong Zhang, Shashi Kant Tiwari, Gianluigi Lichinchi, Edwin H. Yau, Hui Hui, Wanyu Li, Frank Furnari, Tariq M. RanaSummaryWe perform a CRISPR-Cas9 genome-wide screen in glioblastoma stem cells and identify integrin αvβ5 as an internalization factor for Zika virus (ZIKV). Expression of αvβ5 is correlated with ZIKV susceptibility in various cells and tropism in developing human cerebral cortex. A blocking antibody against integrin αvβ5, but not αvβ3, efficiently inhibits ZIKV infection. ZI...
Source: Cell Reports - Category: Cytology Source Type: research
New J. Chem., 2020, Advance Article DOI: 10.1039/C9NJ05225A, Paper Mayank, Deepak Kumar, Navneet Kaur, Rajanish Giri, Narinder Singh Competitive NTPase inhibition and the potential binding to the RNA binding pocket of Zika NS3-helicase were observed using biscoumarin derivatives. The SAR was established, and MN-9 and MN-10 were identified as potent anti-Zika leads. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Comparison Between Larval Survey Index and Positive Ovitrap Index in the Evaluation of Populations of Aedes (Stegomyia) aegypti (Linnaeus, 1762) North of Paraná, Brazil. Environ Health Insights. 2020;14:1178630219886570 Authors: Nascimento KLC, da Silva JFM, Zequi JAC, Lopes J Abstract Aedes (Stegomyia) aegypti (Linnaeus, 1762) is one of the world's most widely distributed mosquitoes and is the vector of the dengue virus, one of the most important reemerging diseases. Besides dengue, A. aegypti can also transmit urban yellow fever, chikungunya, and Zika virus, making it of great medical importa...
Source: Environmental Health Insights - Category: Environmental Health Authors: Tags: Environ Health Insights Source Type: research
No abstract available
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Current Abstracts Source Type: research
(University of California - San Diego) Two different UC San Diego research teams identified the same molecule --αvβ5 integrin -- as Zika virus' key to brain cell entry. They found ways to take advantage of the integrin to both block Zika virus from infecting cells and turn it into something good: a way to shrink brain cancer stem cells.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
In this study, we screened a fragment compound library against the Zika protease using a primary thermal shift assay and identified twenty-two fragments which (bind to and) stabilize the protease. We then determined the X-ray crystal structures of two hits from different classes, all of which bind to the S1 pocket next to the protease active site. We confirmed that these two fragments bind to the protease without inducing significant conformational changes using solution NMR spectroscopy. These fragment scaffolds serve as the starting point for subsequent lead compound development.
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 14 January 2020Source: Journal of Theoretical BiologyAuthor(s): Gonzalo P. Suarez, Oyita Udiani, Brian F. Allan, Candice Price, Sadie J. Ryan, Eric Lofgren, Alin Coman, Chris M. Stone, Lazaros K. Gallos, Nina H. FeffermanAbstractEffective public health measures must balance potentially conflicting demands from populations they serve. In the case of infectious disease risks from mosquito–borne infections, such as Zika virus, public concern about the pathogen may be counterbalanced by public concern about environmental contamination from chemical agents used for vector control. Here w...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
A. Iqbal et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
Zika virus (ZIKV) infection during pregnancy can cause serious birth defects, including brain and eye abnormalities. The clinical importance of detection of ZIKV ribonucleic acid (RNA) in amniotic fluid is unknown.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Original Research: Obstetrics Source Type: research
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