Re: Cholinesterase inhibitors for patients with Alzheimer 's disease: systematic review of randomised clinical trials

Source: BMJ Comments - Category: General Medicine Source Type: forums

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The materials here report on efforts to screen for small molecule compounds that can reduce the age-related decline of mitochondrial function observed in neurons - and indeed throughout the body. Screening the contents of compound libraries is a process that might sound simple, and conceptually it is, but it is a complex task to build a cost-effective system and supporting logistics to screen for a novel outcome. In this case the outcome is a reversal of at least some degree of reduced mitochondrial function in neurons from old tissue, as well as improvement in important aspects of neural function. Every cell contai...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
CONCLUSIONS: The type and characteristics of CS exercises have an impact on the engagement level of AD patients with mild to moderate dementia. Further studies are necessary to better understand which characteristics of the exercises affect the engagement of the patient according to their particularities. This kind of study may help the design of CS sessions and improve the results obtained. PMID: 31940610 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Authors: Wang X, Zhao J Abstract Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder causing progressive memory loss and cognitive impairment. The aberrant accumulation of amyloid‑β (Aβ) and neuroinflammation are two major events in AD. Aβ‑induced neurotoxicity and oxidative stress are also involved in the pathogenesis of AD. The purpose of the current study was to investigate the effect of compound porcine cerebroside and ganglioside injection (CPCGI) on the progression of AD, and to explore the molecular mechanism. In vivo and in vitro models of AD were established...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
CONCLUSION: In comparison to a dichotomous threshold, considering the most error-prone test scores as uncertain enables a classification that offers adequate classification accuracies in a larger number of clinical settings. PMID: 31934880 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Publication date: May 2020Source: Materials Science and Engineering: C, Volume 110Author(s): T.K. Henna, K. PramodAbstractCarbon-based nanomaterials have established a prime position as drug delivery carriers. It is very interesting to see that a carbon nanostructure could be used as a drug too, instead of its regular application as a drug delivery carrier. In this aspect, graphene quantum dots (GQDs) are now in the spotlight. GQDs are one of the recent entrants to the list of carbon-based nanomaterials. They are now reported useful in Parkinson's and Alzheimer's diseases. Furthermore, antibacterial and anti-diabetic poten...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
This study simulated the pathological process associated with AD and proposed that hypoxia of intravascular cells with normal blood oxygen saturation might be one of a pathogenic mechanisms of AD. Therefore, this work may provide a new theoretical basis for AD prevention and treatment. PMID: 31934303 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
It ’s not just a modern problem. Airborne toxins are so pernicious that they may have shaped our DNA over millions of years.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Genetics and Heredity Smoking and Tobacco Alzheimer ' s Disease Wildfires Air Pollution Hazardous and Toxic Substances Evolution (Biology) Lungs Factories and Manufacturing Silica Deaths (Fatalities) Quarterly Review of Biology, Source Type: news
Authors: Sittler MC, Meichsner F, Wilz G Abstract The present study examined the factor structure of a German questionnaire version of the Behavioral Pathology in Alzheimer's Disease Scale (BEHAVE-AD), which originally assesses behavioral disturbances in people with dementia independent from cognitive symptoms in a clinical interview with a caregiver. The 7-factor structure of the interview version of the BEHAVE-AD (i. e., Paranoid and Delusional Ideation, Hallucinations, Activity Disturbances, Aggressiveness, Diurnal Rhythm Disturbances, Affective Disturbances, Anxieties and Phobias) could not be confirmed ...
Source: PPmP Psychotherapie Psychosomatik Medizinische Psychologie - Category: Psychiatry & Psychology Tags: Psychother Psychosom Med Psychol Source Type: research
I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role is to be evidence for a lack of correlation between amyloid-β and cognitive decline. When thinking about the early stages of loss of cognitive function, in which changes are small and subtle, one might have to consider other factors such as vascular dysfunction or other neurodegenerative conditions with quite different mechanisms that could produce these effects. The interplay and relative importance of the...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Publication date: Available online 14 January 2020Source: NeuroImage: ClinicalAuthor(s): Kathryn M. Broadhouse, Maria Fiatarone Singh, Chao Suo, Nicola Gates, Wei Wen, Henry Brodaty, Nidhi Jain, Guy C. Wilson, Jacinda Meiklejohn, Nalin Singh, Bernhard T. Baune, Michael Baker, Nasim Foroughi, Yi Wang, Nicole Kochan, Kevin Ashton, Matt Brown, Zhixiu Li, Yorgi Mavros, Perminder S. SachdevABSTRACTDementia affects 47 million individuals worldwide, and assuming the status quo is projected to rise to 150 million by 2050. Prevention of age-related cognitive impairment in older persons with lifestyle interventions continues to garn...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
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