Brief Update on Dermatologic Uses of Methotrexate

Brief Update on Dermatologic Uses of Methotrexate Skin Therapy Lett. 2019 Nov;24(6):5-8 Authors: Shah RA, Nwannunu CE, Limmer AL, Patel RR, Mui UN, Tyring SK Abstract Methotrexate (MTX), an agent originally intended for anti-neoplastic use, has been successfully employed in the treatment of a variety of dermatologic conditions. In addition to its multiple clinical indications, variable dosing and modes of administration make it a viable option for patients of all ages and most comorbidities. MTX is a folate analog that antagonizes dihydrofolate reductase, thus inhibiting thymidylate synthesis and, ultimately, the production of pyrimidine. Depending on dosage, MTX can function as an anti-inflammatory agent, immunomodulator, or antimetabolite. Patients suffering from psoriasis have benefited from MTX in addition to those with atopic dermatitis, chronic urticaria, pemphigus vulgaris, bullous pemphigoid, cutaneous lupus erythematosus, cutaneous sarcoidosis, and mycosis fungoides. Although patients with these conditions can benefit from MTX treatment, the drug can cause adverse sequelae, including hematologic, pulmonary, gastrointestinal, and hepatic side effects. Therefore, the drug should be administered under careful physician supervision. PMID: 31801013 [PubMed - in process]
Source: Skin Therapy Letter - Category: Dermatology Authors: Tags: Skin Therapy Lett Source Type: research

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Publication date: Available online 30 March 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): J. Magdaleno-Tapial, C. Valenzuela-Oñate, Á. Esteban Hurtado, J.M. Ortiz-Salvador, D. Subiabre-Ferrer, B. Ferrer-Guillén, M. Giacaman-von der Weth, M. García-Legaz Martínez, Á. Martínez-Domenech, P. Hernández-Bel, A. Esteve-Martínez, G. Pérez-Pastor, V. Zaragoza-Ninet, A. García-Rabasco, A. Martínez-Aparicio, J.L. Sánchez-Carazo, A. Pérez-Ferriols, V. Alegre-de Miquel
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
We present a case of a 51 ‐year‐old Japanese woman diagnosed with eosinophilic granulomatous polyangiitis (EGPA), a rare vasculitis that can occur in patients with eosinophilia and history of asthma, allergic rhinitis, and sinusitis, with immunoglobulin (Ig) G4 hypergammaglobulinaemia and salivary gland swelling. AbstractA 51 ‐year‐old woman was admitted to our hospital for cough, fever, purpura in the legs, and salivary gland swelling. Six years ago, she had been diagnosed with bronchial asthma and was treated with a combination of inhaled corticosteroid and long‐acting beta2‐agonist. Blood examination showed ...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
AbstractLevocetirizine is classified as a second ‐generation antihistamine. Levocetirizine is available for the treatment of allergic disorders such as allergic rhinitis and chronic idiopathic urticaria. This was a single‐center, single‐dose, open‐label, randomized, 2‐way crossover study in healthy Japanese male subjects consisting of 2 parts. Part 1 compared the bioavailability of levocetirizine oral disintegrating tablet (ODT) and levocetirizine immediate‐release tablet (IRT) taken with water in the fasted state in 24 subjects; all subjects completed this part of the trial. In part 2, the bioavailability of l...
Source: Clinical Pharmacology in Drug Development - Category: Drugs & Pharmacology Authors: Tags: Original Manuscript Source Type: research
In this study, we re port a library of 73 novel psoralens, the largest collection of its kind. When screened for the ability to induce cell death, we identified two derivatives even more cytotoxic than 4’‐aminomethyl‐4,5’,8‐trimethylpsoralen (AMT), one of the most potent psoralens identified to date. Using MAL DI‐TOF MS, we studied the DNA adduct formation of a subset of novel psoralens and found that in most cases enhanced DNA binding correlated well with cytotoxicity. Generally, our most active derivatives contain positively charged substituents, which we believe increase DNA affinity and enhance psor...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
AbstractIntroductionSeveral factors have been associated with the development of preeclampsia in women with systemic lupus erythematosus (SLE).ObjectiveTo identify risk factors associated with preeclampsia in patients with SLE and its impact on fetal outcomes.Patients and methodsWe studied a prospective cohort of pregnancies in women with SLE from January 2009 to December 2018. Demographic, clinical, serological and drug use characteristics were compared between patients who developed preeclampsia and those who did not, as well as the main neonatal outcomes. An adjusted logistic regression analysis was performed to identif...
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ObjectiveGenetic variants in the region of tumor necrosis factor –induced protein 3–interacting protein 1 (TNIP1) are associated with autoimmune disease and reducedTNIP1 gene expression. The aim of this study was to define the functional genetic mechanisms drivingTNIP1 hypomorphic expression imparted by the systemic lupus erythematosus –associatedTNIP1 H1 risk haplotype.MethodsDual luciferase expression and electrophoretic mobility shift assays were used to evaluate the allelic effects of 11 risk variants on enhancer function and nuclear protein binding in immune cell line models (Epstein ‐Barr virus [E...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
Conditions:   Atopic Dermatitis;   Pruritus;   Pruritus Chronic;   Dermatitis Interventions:   Drug: Naltrexone;   Other: Placebo Sponsor:   University of Minnesota Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: Palmoplantar pustulosis appears to be a distinct entity from psoriasis. Routine thyroid functions test could be analyzed, but patch testing is not required in patients with palmoplantar pustulosis. Also, patients with palmoplantar pustulosis must be evaluated for musculoskeletal symptoms and signs.
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
Conclusion: This is the first Argentine study that evaluated the costs of moderate/severe psoriasis by taking into consideration the direct medical costs of the disease.
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
Conclusion: CYP2J2 50G>T (rs890293) polymorphism was associated with an increased risk for PsV in the Turkish population.
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
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