The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

Publication date: Available online 5 December 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Yahyah Aman, Johannes Frank, Sofie Hindkjær Lautrup, Adrian Matysek, Zhangming Niu, Guang Yang, Liu Shi, Linda H. Bergersen, Jon Storm-Mathisen, Lene J. Rasmussen, Vilhelm A. Bohr, Hilde Nilsen, Evandro F. FangAbstractNicotinamide adenine dinucleotide (NAD+) is an important natural molecule involved in fundamental biological processes, including the TCA cycle, OXPHOS, β-oxidation, and is a co-factor for proteins promoting healthy longevity. NAD+ depletion is associated with the hallmarks of ageing and may contribute to a wide range of age-related diseases including metabolic disorders, cancer, and neurodegenerative diseases. One of the central pathways by which NAD+ promotes healthy ageing is through regulation of mitochondrial homeostasis via mitochondrial biogenesis and the clearance of damaged mitochondria via mitophagy. Here, we highlight the contribution of the NAD+-mitophagy axis to ageing and age-related diseases, and evaluate how boosting NAD+ levels may emerge as a promising therapeutic strategy to counter ageing as well as neurodegenerative diseases including Alzheimer’s disease. The potential use of artificial intelligence to understand the roles and molecular mechanisms of the NAD+-mitophagy axis in ageing is discussed, including possible applications in drug target identification and validation, compound screening and lead compound discovery, biomarker dev...
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research