The Chemical Exposome of Type 2 Diabetes Mellitus: Opportunities and Challenges in the Omics Era
Publication date: Available online 6 December 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Biswapriya B. Misra, Anoop MisraAbstractT2DM, variously known as diabetes mellitus type 2, adult-onset diabetes; noninsulin-dependent diabetes mellitus (NIDDM) is a global silent killer, with> 450 million adults affected worldwide. A diverse array of non-modifiable risk factors such as family history, age (>45 yrs), race/ethnicity, and history of gestational diabetes) and modifiable risk factors such as physical inactivity, high body fat or body weight, high blood pressure and high cholesterol for progression of prediabetes to T2DM. Given, the modern world human population is constantly exposed to multiple stressors in the form of physical (i.e., sound) and chemical environment (i.e., diet, pollutants), industrialization and modernization has led to exposomal correlation with T2DM. Over the past decade, there have been emerging reports on correlation of levels of persistent organic pollutants (POPs), phthalates, antibiotics, drugs, air pollution, pesticides, and heavy metals with T2DM. In this review, we discuss the chemical exposome that has been associated with T2DM; the tools and approaches to capture this chemical exposome and future opportunities and challenges in this exciting area of research. We further provide a window of thoughts, whether omics technologies can help fill in the gaps to help provide high throughput exposomics datasets in an u...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
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